Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence.

Détails

ID Serval
serval:BIB_54061ADF9C93
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence.
Périodique
Journal of the American College of Cardiology
Auteur(s)
Meister T.A., Rimoldi S.F., Soria R., von Arx R., Messerli F.H., Sartori C., Scherrer U., Rexhaj E.
ISSN
1558-3597 (Electronic)
ISSN-L
0735-1097
Statut éditorial
Publié
Date de publication
11/09/2018
Peer-reviewed
Oui
Volume
72
Numéro
11
Pages
1267-1274
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown.
This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group.
Five years after the initial assessment, the study investigators reassessed vascular function and performed 24-h ambulatory blood pressure (BP) monitoring (ABPM) in 54 young, apparently healthy participants conceived through ART and 43 age- and sex-matched controls.
Premature vascular aging persisted in ART-conceived subjects, as evidenced by a roughly 25% impairment of flow-mediated dilation of the brachial artery (p < 0.001) and increased pulse-wave velocity and carotid intima-media thickness. Most importantly, ABPM values (systolic BP, 119.8 ± 9.1 mm Hg vs. 115.7 ± 7.0 mm Hg, p = 0.03; diastolic BP, 71.4 ± 6.1 mm Hg vs. 69.1 ± 4.2 mm Hg, p = 0.02 ART vs. control) and BP variability were markedly higher in ART-conceived subjects than in control subjects. Eight of the 52 ART participants, but only 1 of the 43 control participants (p = 0.041 ART vs. controls) fulfilled ABPM criteria of arterial hypertension (>130/80 mm Hg and/or >95th percentile).
ART-induced premature vascular aging persists in apparently healthy adolescents and young adults without any other detectable classical cardiovascular risk factors and progresses to arterial hypertension. (Vascular Dysfunction in Offspring of Assisted Reproduction Technologies; NCT00837642.).
Mots-clé
Adolescent, Blood Pressure Monitoring, Ambulatory, Brachial Artery/diagnostic imaging, Brachial Artery/physiopathology, Carotid Arteries/physiopathology, Carotid Intima-Media Thickness, Case-Control Studies, Endothelium, Vascular/diagnostic imaging, Endothelium, Vascular/physiopathology, Female, Femoral Artery/physiopathology, Humans, Hypertension/diagnosis, Hypertension/epidemiology, Male, Pulse Wave Analysis, Reproductive Techniques, Assisted/adverse effects, Switzerland/epidemiology, Ultrasonography, Vascular Stiffness/physiology, Vasodilation/physiology, Young Adult, arterial hypertension, assisted reproductive technologies, endothelial dysfunction, flow-mediated dilation
Pubmed
Web of science
Création de la notice
24/09/2018 13:18
Dernière modification de la notice
18/09/2019 5:10
Données d'usage