Live attenuated Salmonella: a paradigm of mucosal vaccines

Détails

ID Serval
serval:BIB_53EE389C8195
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Live attenuated Salmonella: a paradigm of mucosal vaccines
Périodique
Immunological Reviews
Auteur⸱e⸱s
Sirard  J. C., Niedergang  F., Kraehenbuhl  J. P.
ISSN
0105-2896 (Print)
Statut éditorial
Publié
Date de publication
10/1999
Volume
171
Pages
5-26
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Résumé
Two key steps control immune responses in mucosal tissues: the sampling and transepithelial transport of antigens, and their targeting into professional antigen-presenting cells in mucosa-associated lymphoid tissue. Live Salmonella bacteria use strategies that allow them to cross the epithelial barrier of the gut, to survive in antigen-presenting cells where bacterial antigens are processed and presented to the immune cells, and to express adjuvant activity that prevents induction of oral tolerance. Two Salmonella serovars have been used as vaccines or vectors, S. typhimurium in mice and S. typhi in humans. S. typhimurium causes gastroenteritis in a broad host range, including humans, while S. typhi infection is restricted to humans. Attenuated S. typhimurium has been used successfully in mice to induce systemic and mucosal responses against more than 60 heterologous antigens. This review aims to revisit S. typhimurium-based vaccination, as an alternative to S. typhi, with special emphasis on the molecular pathogenesis of S. typhimurium and the host response. We then discuss how such knowledge constitutes the basis for the rational design of novel live mucosal vaccines.
Mots-clé
Animals Bacterial Vaccines/*immunology Humans Mice Mucous Membrane/immunology Salmonella Infections/immunology/*prevention & control Salmonella typhi/genetics/immunology/pathogenicity Salmonella typhimurium/genetics/immunology/pathogenicity Typhoid Fever/*prevention & control Vaccines, Attenuated/*immunology Vaccines, Synthetic/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 15:08
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