Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles

Détails

ID Serval
serval:BIB_53B11B2BEFAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles
Périodique
European Journal of Immunology
Auteur(s)
Schwarz  K., Meijerink  E., Speiser  D. E., Tissot  A. C., Cielens  I., Renhof  R., Dishlers  A., Pumpens  P., Bachmann  M. F.
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
03/2005
Volume
35
Numéro
3
Pages
816-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
Induction of high frequencies of specific T cells by vaccination requires prime-boost regimens. To reach optimal immune responses, it is necessary to use different vectors for priming and boosting as e.g. DNA vaccination followed by boosting with a recombinant viral vector. Here, we show that vaccines based on virus-like particles (VLP) displaying peptide epitopes are equally effective to induce CTL responses if used in a homologous or heterologous prime-boost setting. Strikingly, high frequencies (>20% of CD8(+) cells) of protective CTL could be induced and maintained by weekly injection of VLP. Thus, the use of VLP may avoid the requirement for complicated heterologous prime-boost regimens, facilitating the development of effective T cell-based vaccines.
Mots-clé
Animals CpG Islands/immunology Epitopes, T-Lymphocyte/immunology Female Hepatitis B Core Antigens/*immunology Mice T-Lymphocytes/*immunology Vaccination/*methods *Vaccines, DNA Vaccinia/immunology Vaccinia virus/immunology Viral Vaccines/immunology Virion/*immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
20/08/2019 15:08
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