Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.

Détails

ID Serval
serval:BIB_5385B6186984
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.
Périodique
American Journal of Pathology
Auteur⸱e⸱s
Brauchle M., Madlener M., Wagner A.D., Angermeyer K., Lauer U., Hofschneider P.H., Gregor M., Werner S.
ISSN
0002-9440 (Print)
ISSN-L
0002-9440
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
149
Numéro
2
Pages
521-529
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Recently we demonstrated an important function of keratinocyte growth factor (KGF) in wound re-epithelialization. As KGF is mitogenic for various epithelial cells, we speculated about a role of KGF in epithelial repair processes of other organs as seen in a variety of inflammatory diseases. Here we demonstrate a strikingly increased expression of KGF in surgical specimens from patients suffering from Crohn's disease and ulcerative colitis. The levels of KGF expression strongly correlated with the degree of inflammation as assessed by histological analysis of adjacent tissue and expression analysis of the pro-inflammatory cytokine interleukin-1 beta. The highest levels of KGF mRNA and protein were found in mesenchymal cells of the lamina propria, particularly in highly inflamed areas. As the KGF receptor is expressed in intestinal epithelial cells, KGF seems to act in a paracrine manner to stimulate proliferation of these cells. These data suggest a crucial role of KGF in epithelial repair after injury caused by inflammatory processes.
Mots-clé
Blotting, Western, Colitis, Ulcerative/pathology, Colitis, Ulcerative/physiopathology, Crohn Disease/pathology, Crohn Disease/physiopathology, Fibroblast Growth Factor 10, Fibroblast Growth Factor 7, Fibroblast Growth Factors, Growth Substances/biosynthesis, Growth Substances/genetics, Humans, Ileum/metabolism, Ileum/pathology, In Situ Hybridization, Interleukin-1/analysis, RNA, Messenger/analysis, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Fibroblast Growth Factor, Receptors, Growth Factor/analysis
Pubmed
Web of science
Création de la notice
16/02/2016 17:31
Dernière modification de la notice
20/08/2019 14:08
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