Epirubicin and ifosfamide in advanced soft tissue sarcoma: a phase II study

Détails

ID Serval
serval:BIB_53575370165E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Epirubicin and ifosfamide in advanced soft tissue sarcoma: a phase II study
Périodique
Cancer Investigation
Auteur(s)
Chevallier  B., Leyvraz  S., Olivier  J. P., Fargeot  P., Facchini  T., Vo Van  M. L.
ISSN
0735-7907 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
11
Numéro
2
Pages
135-9
Notes
Clinical Trial
Clinical Trial, Phase II
Journal Article
Résumé
Thirty patients with previously untreated and measurable or evaluable advanced soft tissue sarcoma entered this phase II study. Median age was 53 years (range: 24-71 years). Starting dose of Epirubicin was 100 mg/m2 IV bolus on day 1 combined with Ifosfamide, 2.5 g/m2, as a 6-hr IV infusion on day 1 and day 2 with uroprotection with Uromitexan, 1.6 g/m2, on day 1 and day 2. This schedule was repeated every 3 weeks. In case of minimal myelosuppression, the dose of Epirubicin was increased by 10 mg/m2 up to 130 mg/m2. Ifosfamide dosage was not increased. Mean cumulative dose of Epirubicin received was 477 +/- 272 mg/m2 (range: 200-1200 mg/m2). Of 27 evaluable patients (WHO criteria), 13 had a partial response (48%), 4 showed no change (15%), and 10 had progressive disease (37%). Median time to progression was 27 weeks. Of 27 patients evaluable for toxicity, hematological toxicity at day 21 was mild. Nonhematological toxicities consisted of nausea and vomiting in 82% of patients (WHO grade 3-4 = 19%), stomatitis in 44.5% (WHO grade 3 = 7.5%), and alopecia in 96% (WHO grade 2-3 = 89%). Appearance of cardiac dysfunction without heart failure during the treatment led to discontinuation of this chemotherapy in 3 patients. The results of this study show that the combination of Epirubicin and Ifosfamide is effective in advanced soft tissue sarcoma with an acceptable toxicity. However, we cannot conclude from this trial whether combination Epirubicin and Ifosfamide is superior to Epirubicin alone.
Mots-clé
Adult Aged Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use Drug Administration Schedule Epirubicin/administration & dosage/adverse effects Female Humans Ifosfamide/administration & dosage/adverse effects Male Middle Aged Sarcoma/*drug therapy Soft Tissue Neoplasms/*drug therapy
Pubmed
Web of science
Création de la notice
28/01/2008 9:32
Dernière modification de la notice
20/08/2019 15:08
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