Evaluation of finger ultrasound in the assessment of bone status with application of rheumatoid arthritis.

Détails

ID Serval
serval:BIB_5249FF240769
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evaluation of finger ultrasound in the assessment of bone status with application of rheumatoid arthritis.
Périodique
Osteoporosis International
Auteur(s)
Njeh C.F., Boivin C.M., Gough A., Hans D., Srivastav S.K., Bulmer N., Devlin J., Emery P.
ISSN
0937-941X
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
82-90
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Osteoporosis associated with active rheumatoid arthritis (RA) has been demonstrated in both the axial and peripheral skeleton, especially the periarticular regions more directly affected by the disease. Quantitative ultrasound (QUS) is a recently accepted tool for the assessment of bone status, and therefore could be used to monitor bone changes in RA patients. In a cross-sectional study we measured ultrasound velocity (Ad-SOS) through the proximal phalanges in three groups of female subjects. These included: 51 patients with rheumatoid arthritis (group 1), 44 general practitioner (GP)-referred patients for osteopenia (group 2) and 52 young healthy volunteers (group 3). For groups 1 and 2 bone mineral density (BMD) of the lumbar spine and proximal femur were also measured. For the RA patients BMD of the hand, measurement of hand function (HAQ and grip strength) and disease activity (ESR and CRP) were also assessed. The precision of long-term Ad-SOS measurements on volunteers gave a root mean square coefficient of variation (CV) of 0.7% and standardized CV of 3.6%. No statistically significant effect of dominance was observed in the measured Ad-SOS between the dominant and non-dominant hand (r = 0.96, p < 0.001). Ad-SOS was found to be significantly different in the three groups (p < 0.0001). Ad-SOS was highly dependent on age (r = -0.67), with a gradual reduction (-5.2 m/s per year) after the age of 30 years for female patients in both group 1 and group 2. Ad-SOS was significantly correlated with lumbar spine, femoral neck and hand BMD, with correlation coefficients of 0.49, 0.51 and 0.72 respectively for RA patients. Finger ultrasound was moderately correlated with measures of hand function, with coefficients of 0.37 and 0.39 for HAQ and grip strength respectively. Hand BMD also correlated to the same power with these parameters. Neither finger ultrasound nor BMD was significantly correlated with ESR and CRP (measures of disease activity). We have demonstrated that bone status can be assessed quickly and cheaply using a portable QUS device. Ad-SOS relates to the measure of hand function in RA patients. Longitudinal studies are required to determine the usefulness of finger ultrasound for monitoring disease progression or the effect of treatment in RA.
Mots-clé
Adult, Age Factors, Arthritis, Rheumatoid, Bone Density, Cross-Sectional Studies, Female, Fingers, Humans, Middle Aged, Osteoporosis
Pubmed
Web of science
Création de la notice
02/03/2009 13:33
Dernière modification de la notice
20/08/2019 15:07
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