Atrial natriuretic factor in patients with congenital heart disease: correlation with hemodynamic variables

Détails

ID Serval
serval:BIB_5216E2E91571
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Atrial natriuretic factor in patients with congenital heart disease: correlation with hemodynamic variables
Périodique
Journal of the American College of Cardiology
Auteur(s)
Oberhansli  I., Mermillod  B., Favre  H., Friedli  B., Girardin  E., Paunier  L.
ISSN
0735-1097
Statut éditorial
Publié
Date de publication
05/1990
Peer-reviewed
Oui
Volume
15
Numéro
6
Pages
1438-45
Notes
Journal Article --- Old month value: May
Résumé
To investigate the alpha-atrial natriuretic factor in congenital cardiac malformations, three groups of children, aged 7 months to 16 years, with different hemodynamic situations were studied during routine cardiac catheterization. Twenty-one (group I) had tetralogy of Fallot, 24 (group II) had a left to right shunt with pulmonary hypertension and 12 (control group) had a minor cardiac lesion. Alpha-atrial natriuretic factor levels were determined by a radioimmunoassay on blood samples from the inferior vena cava, right atrium, pulmonary artery, left atrium and aorta. To evaluate the effect of an acute volume load, measurements of hormone and pressures were repeated after right ventriculography. Alpha-atrial natriuretic factor levels varied over a wide range in all groups and in all chambers investigated. Nevertheless, children with pulmonary hypertension had significantly higher levels of the hormone (p less than 0.01) and were well separated from the control group, but less well from those with tetralogy of Fallot. A 50% increase of alpha-atrial natriuretic factor from the inferior vena cava to the right atrium occurred in patients with shunt lesions with pulmonary hypertension and in patients with tetralogy of Fallot (p less than 0.001) and a further 30% increase from the right atrium to the pulmonary artery (p less than 0.05). After right ventriculography, a 100% to 200% increase of alpha-atrial natriuretic factor was observed in the total sample (p less than 0.001). A positive correlation was observed between right atrial mean pressure and right atrial alpha-atrial natriuretic factor (r = 0.63) and between pulmonary artery mean pressure and pulmonary artery alpha-atrial natriuretic factor (r = 0.61).(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adolescent Atrial Natriuretic Factor/blood/*physiology Blood Pressure/physiology Child Child, Preschool Heart Catheterization Heart Defects, Congenital/blood/*physiopathology Heart Ventricles/radiography Hemodynamic Processes/*physiology Humans Hypertension, Pulmonary/physiopathology Infant Pulmonary Artery/physiopathology Regression Analysis Tetralogy of Fallot/physiopathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/01/2008 15:28
Dernière modification de la notice
20/08/2019 15:07
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