Microglia immunometabolism: From metabolic disorders to single cell metabolism.

Détails

ID Serval
serval:BIB_520DECB161CF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Microglia immunometabolism: From metabolic disorders to single cell metabolism.
Périodique
Seminars in cell & developmental biology
Auteur(s)
Paolicelli R.C., Angiari S.
ISSN
1096-3634 (Electronic)
ISSN-L
1084-9521
Statut éditorial
Publié
Date de publication
10/2019
Peer-reviewed
Oui
Volume
94
Pages
129-137
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Since the observation that obesity-associated low-grade chronic inflammation is a crucial driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of studies have highlighted the role of both the innate and the adaptive immune system in such pathologies. Moreover, researchers have recently demonstrated that immune cells can modulate their intracellular metabolic profile to control their activation and effector functions. These discoveries represent the foundations of a research area known as "immunometabolism", an emerging field of investigation that may lead to the development of new-generation therapies for the treatment of inflammatory and metabolic diseases. Most of the studies in the field have focused their attention on both circulating white blood cells and leukocytes residing within metabolic tissues such as adipose tissue, liver and pancreas. However, immunometabolism of immune cells in non-metabolic tissues, including central nervous system microglia, have long been neglected. In this review, we highlight the most recent findings suggesting that microglial cells play a central role in metabolic disorders and that interfering with the metabolic profile of microglia can modulate their functionality and pathogenicity in neurological diseases.
Mots-clé
Animals, Humans, Metabolic Diseases/immunology, Metabolic Diseases/metabolism, Metabolic Diseases/pathology, Microglia/immunology, Microglia/metabolism, Microglia/pathology, Single-Cell Analysis, Immunometabolism, Inflammation, Metabolic diseases, Metabolism, Microglia
Pubmed
Web of science
Création de la notice
15/04/2019 18:39
Dernière modification de la notice
26/06/2020 6:21
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