Nerve growth factor modulates information processing in the auditory thalamus.

Détails

ID Serval
serval:BIB_5196
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nerve growth factor modulates information processing in the auditory thalamus.
Périodique
Brain Research Bulletin
Auteur(s)
Villa A.E., Bajo Lorenzana V.M., Vantini G.
ISSN
0361-9230
Statut éditorial
Publié
Date de publication
1996
Volume
39
Numéro
3
Pages
139-147
Langue
anglais
Résumé
The spatio-temporal organization of spike discharges was studied in rat auditory thalamus (i.e., medial geniculate body and auditory sector of thalamic reticular nucleus) following a 2-week continuous intracerebroventricular administration of nerve growth factor (NGF). Recording of extracellular single-unit activity indicated that, in medial geniculate body, NGF induced a significant increase of the mean firing rate. In thalamic reticular nucleus, where units tend to discharge in bursts, NGF increased the average burst size (number of spikes) and the intraburst frequency without affecting the firing rate. Following white noise acoustical stimulation, in medial geniculate body, more onset excitation and a lower signal-to-noise ratio were observed in NGF-treated rats than in controls. Conversely, in thalamic reticular nucleus, NGF-treated animals showed more inhibitory responses than controls. In addition, within the medial geniculate body, functional interactions between pairs of units simultaneously recorded from different electrodes were greatly increased by the nerve growth factor treatment. These data indicate that modifications of temporal pattern of discharges in selected brain regions are among the effects induced by the intracerebroventricular administration of nerve growth factor.
Mots-clé
Animals, Choline O-Acetyltransferase/drug effects, Evoked Potentials/drug effects, Female, Nerve Growth Factors/pharmacology, Neural Pathways/drug effects, Rats, Thalamus/drug effects, Time Factors
Pubmed
Web of science
Création de la notice
19/11/2007 13:41
Dernière modification de la notice
20/08/2019 15:07
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