Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.

Détails

Ressource 1Télécharger: Fleig Rbpj_Nat Comm 2022.pdf (4699.79 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_513AD0411BD1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Périodique
Nature communications
Auteur⸱e⸱s
Fleig S., Kapanadze T., Bernier-Latmani J., Lill J.K., Wyss T., Gamrekelashvili J., Kijas D., Liu B., Hüsing A.M., Bovay E., Jirmo A.C., Halle S., Ricke-Hoch M., Adams R.H., Engel D.R., von Vietinghoff S., Förster R., Hilfiker-Kleiner D., Haller H., Petrova T.V., Limbourg F.P.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
19/04/2022
Peer-reviewed
Oui
Volume
13
Numéro
1
Pages
2022
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains not well understood. Here we show, using conditional deletion strategies of the canonical Notch signaling mediator Rbpj, that loss of endothelial Notch signaling in adult mice induces the spontaneous formation of bona fide TLS in the kidney, liver and lung, based on molecular, cellular and structural criteria. These TLS form in a stereotypical manner around parenchymal arteries, while secondary lymphoid structures remained largely unchanged. This effect is mediated by endothelium of blood vessels, but not lymphatics, since a lymphatic endothelial-specific targeting strategy did not result in TLS formation, and involves loss of arterial specification and concomitant acquisition of a high endothelial cell phenotype, as shown by transcriptional analysis of kidney endothelial cells. This indicates a so far unrecognized role for vascular endothelial cells and Notch signaling in TLS initiation.
Mots-clé
Animals, Endothelial Cells, Endothelium, Vascular, Inflammation, Mice, Receptors, Notch/genetics, Signal Transduction, Tertiary Lymphoid Structures
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/05/2022 8:53
Dernière modification de la notice
20/07/2022 6:09
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