Cortisol levels and history of depression in acute coronary syndrome patients
Détails
ID Serval
serval:BIB_512191340AC5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cortisol levels and history of depression in acute coronary syndrome patients
Périodique
Psychol Med
ISSN
1469-8978 (Electronic)
ISSN-L
0033-2917
Statut éditorial
Publié
Date de publication
09/2012
Volume
42
Numéro
9
Pages
1815-23
Langue
anglais
Notes
Messerli-Burgy, N
Molloy, G J
Wikman, A
Perkins-Porras, L
Randall, G
Steptoe, A
eng
RG/10/005/28296/British Heart Foundation/United Kingdom
RG/05/006/BHF_/British Heart Foundation/United Kingdom
Research Support, Non-U.S. Gov't
England
Psychol Med. 2012 Sep;42(9):1815-23. doi: 10.1017/S0033291711002959. Epub 2012 Jan 11.
Molloy, G J
Wikman, A
Perkins-Porras, L
Randall, G
Steptoe, A
eng
RG/10/005/28296/British Heart Foundation/United Kingdom
RG/05/006/BHF_/British Heart Foundation/United Kingdom
Research Support, Non-U.S. Gov't
England
Psychol Med. 2012 Sep;42(9):1815-23. doi: 10.1017/S0033291711002959. Epub 2012 Jan 11.
Résumé
BACKGROUND: Depressed mood following an acute coronary syndrome (ACS) is a risk factor for future cardiac morbidity. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with depression, and may be a process through which depressive symptoms influence later cardiac health. Additionally, a history of depression predicts depressive symptoms in the weeks following ACS. The purpose of this study was to determine whether a history of depression and/or current depression are associated with the HPA axis dysregulation following ACS. METHOD: A total of 152 cardiac patients completed a structured diagnostic interview, a standardized depression questionnaire and a cortisol profile over the day, 3 weeks after an ACS. Cortisol was analysed using: the cortisol awakening response (CAR), total cortisol output estimated using the area under the curve method, and the slope of cortisol decline over the day. RESULTS: Total cortisol output was positively associated with history of depression, after adjustment for age, gender, marital status, ethnicity, smoking status, body mass index (BMI), Global Registry of Acute Cardiac Events (GRACE) risk score, days in hospital, medication with statins and antiplatelet compounds, and current depression score. Men with clinically diagnosed depression after ACS showed a blunted CAR, but the CAR was not related to a history of depression. CONCLUSIONS: Patients with a history of depression showed increased total cortisol output, but this is unlikely to be responsible for associations between depression after ACS and later cardiac morbidity. However, the blunted CAR in patients with severe depression following ACS indicates that HPA dysregulation is present.
Mots-clé
Acute Coronary Syndrome/complications/*metabolism/psychology, Aged, Depression/complications/*metabolism, Female, Humans, Hydrocortisone/*analysis, Hypothalamo-Hypophyseal System/*metabolism, Male, Middle Aged, Pituitary-Adrenal System/*metabolism, Risk Factors, Saliva/chemistry, Surveys and Questionnaires
Pubmed
Création de la notice
08/11/2021 18:13
Dernière modification de la notice
10/02/2023 19:46