Prévention des adhérences péricardiques avec une membrane biorésorbable [Prevention of pericardial adhesions with a bioresorbable membrane]

Détails

ID Serval
serval:BIB_50A353FA6B79
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prévention des adhérences péricardiques avec une membrane biorésorbable [Prevention of pericardial adhesions with a bioresorbable membrane]
Périodique
Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera
Auteur⸱e⸱s
Mueller X.M., Tevaearai H.T., Augstburger M., Burki M., von Segesser L.K.
ISSN
1023-9332
Statut éditorial
Publié
Date de publication
1999
Volume
5
Numéro
1
Pages
23-6
Langue
français
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Résumé
A bioresorbable membrane made of sodium hyaluronate and carboxymethycellulose, has been reported to prevent peritoneal adhesion. This study was designed to test its efficiency in the prevention of pericardial adhesions. Two groups of six pigs (mean weight 72 +/- 8 kg) were chosen for the experiment. The heart was exposed through a left thoracotomy and a wide patch of pericardium was excised. In the test group (n = 6), the left ventricular area without pericardium was divided into two areas: area A where six stitches of Prolene were performed, and area B which was left intact. The membrane was applied on the both areas as well as on the adjacent area covered with pericardium (area C). In the control group (n = 6), the same protocol was performed except for the membrane application. The animals were sacrificed one month later. The adhesion status as well as the visibility of the coronary anatomy was assessed according to severity scores ranging from 0 to 3 for the adhesions and from 0 to 2 for the visibility. The difference between groups was considered significant when p < 0.05. The adhesion score of the area A was 1.7 +/- 0.5 in the test group versus 2.5 +/- 0.5 in the control group (p = 0.02) and the visibility score was 1.3 +/- 0.8 and 2 +/- 0 respectively (p = 0.07). In the area B, the adhesion score was 1 +/- 0 in the test group versus 2 +/- 0.6 in the control group (p = 0.03) and the visibility score was 0.7 +/- 0.5 and 2 +/- 0 respectively (p = 0.001). Lastly, in the area C, the adhesion score was 1 +/- 0 in both groups (n.s.) and the visibility score was 0.7 +/- 0.4 in the test group versus 0.5 +/- 0.5 in the control group (n.s.). In this animal model, the role of the bioresorbable membrane in the prevention of pericardial adhesions is limited to the areas without pericardial cover and without foreign material. The presence of foreign material neutralizes its effect.
Mots-clé
Animals, Biocompatible Materials, Heart Diseases, Hyaluronic Acid, Membranes, Artificial, Pericardium, Swine, Tissue Adhesions
Pubmed
Création de la notice
14/02/2008 15:18
Dernière modification de la notice
20/08/2019 15:06
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