The misuse of pregabalin (Lyrica) has emerged as a common problem in recent years, particularly among vulnerable populations. This reality is reflected in the prison environment, where pregabalin is subject to abuse and trafficking. In this article, we detail the issues surrounding this misuse and our practical strategy for tackling it. It is based on four axes: a) clarification of the indication (or lack thereof); b) support of withdrawal with gabapentin; c) if applicable, management of the symptoms or diseases mentioned (neuropathic pain, epilepsy, etc.) with other treatments, and finally d) addiction counseling.