Challenges in developing a consensus definition of neonatal sepsis.

Détails

ID Serval
serval:BIB_506A1AF8F32A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Challenges in developing a consensus definition of neonatal sepsis.
Périodique
Pediatric research
Auteur⸱e⸱s
McGovern M., Giannoni E., Kuester H., Turner M.A., van den Hoogen A., Bliss J.M., Koenig J.M., Keij F.M., Mazela J., Finnegan R., Degtyareva M., Simons SHP, de Boode W.P., Strunk T., Reiss IKM, Wynn J.L., Molloy E.J.
Collaborateur⸱rice⸱s
Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR
ISSN
1530-0447 (Electronic)
ISSN-L
0031-3998
Statut éditorial
Publié
Date de publication
07/2020
Peer-reviewed
Oui
Volume
88
Numéro
1
Pages
14-26
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at present, there is no unified definition of neonatal sepsis. Existing consensus sepsis definitions within paediatrics are not suited for use in the NICU and do not address sepsis in the premature population. Many neonatal research and surveillance networks have criteria for the definition of sepsis within their publications though these vary greatly and there is typically a heavy emphasis on microbiological culture. The concept of organ dysfunction as a diagnostic criterion for sepsis is rarely considered in neonatal literature, and it remains unclear how to most accurately screen neonates for organ dysfunction. Accurately defining and screening for sepsis is important for clinical management, health service design and future research. The progress made by the Sepsis-3 group provides a roadmap of how definitions and screening criteria may be developed. Similar initiatives in neonatology are likely to be more challenging and would need to account for the unique presentation of sepsis in term and premature neonates. The outputs of similar consensus work within neonatology should be twofold: a validated definition of neonatal sepsis and screening criteria to identify at-risk patients earlier in their clinical course. IMPACT: There is currently no consensus definition of neonatal sepsis and the definitions that are currently in use are varied.A consensus definition of neonatal sepsis would benefit clinicians, patients and researchers.Recent progress in adults with publication of Sepsis-3 provides guidance on how a consensus definition and screening criteria for sepsis could be produced in neonatology.We discuss common themes and potential shortcomings in sepsis definitions within neonatology.We highlight the need for a consensus definition of neonatal sepsis and the challenges that this task poses.
Pubmed
Web of science
Création de la notice
05/03/2020 15:02
Dernière modification de la notice
23/10/2020 5:23
Données d'usage