Association of endotoxin and allergens with respiratory and skin symptoms: a descriptive study in laboratory animal workers

Détails

Ressource 1Télécharger: 2017_Oppliger_Endoxotin_postprint.pdf (987.66 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_5029FCC18C70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association of endotoxin and allergens with respiratory and skin symptoms: a descriptive study in laboratory animal workers
Périodique
Annals of Work Exposures and Health
Auteur(s)
Oppliger Anne, Barresi Fabio, Maggi Marion, Schmid-Grendelmeier Peter, Huaux François, Hotz Philipp, Dressel Holger
ISSN
2398-7316 (Electronic)
ISSN-L
2398-7308
Statut éditorial
Publié
Date de publication
01/08/2017
Peer-reviewed
Oui
Volume
61
Numéro
7
Pages
822-835
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In laboratory animal work, allergens are classically considered to play a prominent role in generation of respiratory and skin symptoms. However, recent development may have changed working conditions and require an updating of preventive measures.
In workers exposed to a range of animals besides laboratory mice and rats the relative role of endotoxin, irritants, and allergens in symptom generation was assessed for updating preventative measures and health surveillance.
Eligible workers were recruited from university units in which exposure to rats and/or mice, occurrence of respiratory and/or skin symptoms, and/or a history of animal bites had been reported. Exposure to endotoxin and rat and mouse allergen was assessed (71 half-day personal samples). 'Symptomatic' was defined by work-related ocular, nasal, respiratory, or skin symptoms. A concentration of specific IgE against rat or mouse (e87 and e88) ≥0.35 kU/l defined sensitization. Sensitivity analyses examined the effect of alternative exposure indicators and definitions of 'sensitized' and 'symptomatic'.
From 302 eligible workers, 177 participated. There were 121 and 41 workers in the asymptomatic and non-sensitized and symptomatic but non-sensitized group, respectively. Eight subjects were symptomatic and sensitized. Six sensitized subjects were asymptomatic. One participant could not be assigned to a subgroup. Airborne endotoxin and allergen concentrations were mostly below 20 EU m-3 or the detection limit, respectively. Clinical history showed that irritants and sensitizers other than mouse/rat allergen or endotoxin were a major cause of symptoms. Results were sensitive to the selected exposure indicator and the definition of 'symptomatic'.
Health surveillance programs need to be adapted to include a larger range of allergens and pay more attention to irritants.
Mots-clé
Adolescent, Adult, Air Pollutants, Occupational/adverse effects, Air Pollutants, Occupational/analysis, Air Pollutants, Occupational/immunology, Allergens/analysis, Animal Technicians, Animals, Animals, Laboratory, Endotoxins/analysis, Female, Health Surveys, Humans, Hypersensitivity/immunology, Immunoglobulin E/analysis, Male, Mice, Middle Aged, Occupational Exposure/analysis, Rats, Universities, Young Adult, asthma, irritants, laboratory animal, rhinitis, sensitizers
Pubmed
Web of science
Création de la notice
30/08/2017 17:14
Dernière modification de la notice
20/08/2019 15:06
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