Patient and public involvement (PPI) in research is increasingly recognized and encouraged by public and funding bodies. Although gaining momentum, the implementation of PPI in Switzerland remains recent. Since 2021, the Laboratoire des Patients, affiliated to the Swiss Cancer Center Léman (SCCL), aims to establish a PPI model for oncology research adapted to the local context that will assist researchers to apply PPI approaches within their projects. Among its functions, the Laboratoire des Patients will offer a training program for patients and researchers targeting PPI in research, support throughout the projects, and consultation and mediation services for patients and researchers. This article discusses the utility of PPI in research and describes the SCCL-PPI model.