Primary motor cortex involvement in Alzheimer disease.

Détails

ID Serval
serval:BIB_4F6609F627E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Primary motor cortex involvement in Alzheimer disease.
Périodique
Journal of neuropathology and experimental neurology
Auteur⸱e⸱s
Suvà D., Favre I., Kraftsik R., Esteban M., Lobrinus A., Miklossy J.
ISSN
0022-3069
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
58
Numéro
11
Pages
1125-34
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article - Publication Status: ppublish
Résumé
In Alzheimer disease (AD) the involvement of entorhinal cortex, hippocampus, and associative cortical areas is well established. Regarding the involvement of the primary motor cortex the reported data are contradictory. In order to determine whether the primary motor cortex is involved in AD, the brains of 29 autopsy cases were studied, including, 17 cases with severe cortical AD-type changes with definite diagnoses of AD, 7 age-matched cases with discrete to moderate cortical AD-type changes, and 5 control cases without any AD-type cortical changes. Morphometric analysis of the cortical surface occupied by senile plaques (SPs) on beta-amyloid-immunostained sections and quantitative analysis of neurofibrillary tangles (NFTs) on Gallyas-stained sections was performed in 5 different cortical areas including the primary motor cortex. The percentage of cortical surface occupied by SPs was similar in all cortical areas, without significant difference and corresponded to 16.7% in entorhinal cortex, 21.3% in frontal associative, 16% in parietal associative, and 15.8% in primary motor cortex. The number of NFTs in the entorhinal cortex was significantly higher (41 per 0.4 mm2), compared with those in other cortical areas (20.5 in frontal, 17.9 in parietal and 11.5 in the primary motor cortex). Our findings indicate that the primary motor cortex is significantly involved in AD and suggest the appearance of motor dysfunction in late and terminal stages of the disease.
Mots-clé
Adult, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Protein, Brain Chemistry, Entorhinal Cortex, Humans, Middle Aged, Motor Cortex, Neurofibrillary Tangles, Parietal Lobe, Senile Plaques, Somatosensory Cortex
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 18:35
Dernière modification de la notice
20/08/2019 14:05
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