Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting.

Détails

ID Serval
serval:BIB_4F2A32ECC9A7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting.
Périodique
Clinical and experimental immunology
Auteur(s)
Yu Y.R., Ho P.C.
ISSN
1365-2249 (Electronic)
ISSN-L
0009-9104
Statut éditorial
Publié
Date de publication
08/2019
Peer-reviewed
Oui
Volume
197
Numéro
2
Pages
153-160
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Cancer immunotherapy unleashing the power of host immunity on eliminating cancer cells represents a critical advance in cancer treatment; however, effective anti-tumor responses are largely dampened by the immunosuppressive tumor microenvironment (TME). Emerging studies have revealed that physiological features in the TME, including glucose deprivation, hypoxia and low pH, established by the metabolically dysregulated cancer cells restrict anti-tumor immunity by impeding the metabolic fitness of tumor-infiltrating cytotoxic CD8 <sup>+</sup> T cells and natural killer (NK) cells. Furthermore, infiltrating immunomodulatory cells with different metabolic preferences also facilitate the establishment of the immunosuppressive TME. Therefore, deciphering the metabolic cross-talk between immune cells and cancer cells in the TME and elucidating the impact of this process during tumorigenesis are needed to harness anti-tumor immunity more effectively. Herein, we summarize the immunosuppressive features of TME and how these features impair anti-tumor immunity. Moreover, we postulate how immune cells may be involved in shaping the metabolic features of cancer cells and discuss how we might improve the anti-tumor functions of tumor-specific T cells by rewiring their metabolic regulations.
Mots-clé
Animals, CD8-Positive T-Lymphocytes/immunology, Humans, Immune System, Immunity, Immunomodulation, Killer Cells, Natural/immunology, Neoplasms/immunology, Tumor Escape, Tumor Microenvironment, immunoediting, immunometabolism, tumor microenvironment
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/04/2019 16:34
Dernière modification de la notice
27/04/2020 6:20
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