Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders.

Détails

ID Serval
serval:BIB_4ED46FA7FF3F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders.
Périodique
Acta Neuropathologica
Auteur⸱e⸱s
Hof P.R., Nimchinsky E.A., Buée-Scherrer V., Buée L., Nasrallah J., Hottinger A.F., Purohit D.P., Loerzel A.J., Steele J.C., Delacourte A.
ISSN
0001-6322 (Print)
ISSN-L
0001-6322
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
88
Numéro
5
Pages
397-404
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Amyotrophic lateral sclerosis/parkinsonism-dementia complex (lytico-bodig) is a chronic neurodegenerative disorder with high prevalence among the native Chamorro population of Guam. Neuropathological, biochemical, and immunohistochemical analyses were performed on a relatively large series of Guamanian cases and compared to Alzheimer's disease cases. Thioflavin S and antibodies to amyloid beta A4 and tau proteins were used for analysis of pathological changes, and antibodies to the calcium-binding proteins parvalbumin and calretinin, and to a nonphosphorylated epitope on neurofilament protein to study select neuronal populations. A differential distribution of neurofibrillary tangles was observed in the neocortex of Guamanian cases compared to Alzheimer's disease cases, with much higher lesion counts in supragranular than in infragranular layers. Also, Guamanian cases with predominant parkinsonism had generally higher neurofibrillary tangle densities than cases with predominant amyotrophic lateral sclerosis. In addition, there was a certain degree of heterogeneity, qualitatively and quantitatively, in the biochemical distribution of tau proteins among Guamanian and Alzheimer's disease cases as revealed by Western blot analysis. Previous studies have suggested that the clinical symptomatology observed in patients suffering from Alzheimer's disease is related to the dramatic loss of specific corticocortically projecting neurons in the neocortex. Interestingly, a subset of neurofilament-rich pyramidal neurons known to be dramatically affected in Alzheimer's disease appears to be resistant in lytico-bodig. Finally, as in Alzheimer's disease, calcium-binding protein-containing interneurons are not affected. These data suggest that the set of projection neurons affected in Guamanian cases may not correspond to those involved in Alzheimer's disease, and that both disorders are characterized by specific patterns of neuronal vulnerability.
Mots-clé
Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis/pathology, Brain/pathology, Dementia/pathology, Guam, Humans, Immunohistochemistry, Middle Aged, Nerve Degeneration, Nervous System Diseases/pathology, Neurofibrillary Tangles/pathology, Neurons/pathology, Parkinson Disease/pathology
Pubmed
Création de la notice
19/02/2014 21:39
Dernière modification de la notice
20/08/2019 14:04
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