Application of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi-institutional study.

Détails

ID Serval
serval:BIB_4EB236EBF5A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Application of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi-institutional study.
Périodique
Cancer cytopathology
Auteur(s)
Maleki Z., Baloch Z., Lu R., Shafique K., Song S.J., Viswanathan K., Rao R.A., Lefler H., Fatima A., Wiles A., Jo V.Y., Wang H., Fadda G., Powers C.N., Ali S.Z., Pantanowitz L., Siddiqui M.T., Nayar R., Klijanienko J., Barkan G.A., Krane J.F., Rossi E.D., Callegari F., Kholová I., Bongiovanni M., Faquin W.C., Pusztaszeri M.P.
ISSN
1934-6638 (Electronic)
ISSN-L
1934-662X
Statut éditorial
Publié
Date de publication
05/2019
Peer-reviewed
Oui
Volume
127
Numéro
5
Pages
306-315
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a 6-tier diagnostic category system with associated risks of malignancy (ROMs) and management recommendations. Submandibular gland fine-needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a higher relative proportion of malignancy, and this may affect the ROM and subsequent management. This study evaluated the application of the MSRSGC and the ROM for each diagnostic category for 734 submandibular gland FNAs.
Submandibular gland FNA cytology specimens from 15 international institutions (2013-2017) were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. A correlation with the available histopathologic follow-up was performed, and the ROM was calculated for each MSRSGC diagnostic category.
The case cohort of 734 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 21.4% (0%-50%); nonneoplastic, 24.2% (9.1%-53.6%); AUS, 6.7% (0%-14.3%); benign neoplasm, 18.3% (0%-52.5%); SUMP, 12% (0%-37.7%); SM, 3.5% (0%-12.5%); and malignant, 13.9% (2%-31.3%). The histopathologic follow-up was available for 333 cases (45.4%). The ROMs were as follows: nondiagnostic, 10.6%; nonneoplastic, 7.5%; AUS, 27.6%; benign neoplasm, 3.2%; SUMP, 41.9%; SM, 82.3%; and malignant, 93.6%.
This multi-institutional study shows that the ROM of each MSRSGC category for submandibular gland FNA is similar to that reported for parotid gland FNA, although the reported rates for the different MSRSGC categories were variable across institutions. Thus, the MSRSGC can be reliably applied to submandibular gland FNA.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Biopsy, Fine-Needle, Child, Child, Preschool, Cytodiagnosis/methods, Cytodiagnosis/standards, Female, Follow-Up Studies, Health Facilities, Humans, Infant, International Agencies, Male, Medical Records/statistics & numerical data, Middle Aged, Precancerous Conditions/diagnosis, Retrospective Studies, Risk Assessment/methods, Salivary Gland Neoplasms/classification, Salivary Gland Neoplasms/diagnosis, Submandibular Gland/pathology, Young Adult, Milan System for Reporting Salivary Gland Cytopathology (MRSSGC), atypia of undetermined significance (AUS), benign neoplasm, fine-needle aspiration (FNA), malignant, nondiagnostic, nonneoplastic, risk of malignancy (ROM), salivary gland neoplasm of uncertain malignant potential (SUMP), submandibular gland, suspicious for malignancy (SM)
Pubmed
Web of science
Création de la notice
14/05/2019 13:08
Dernière modification de la notice
27/04/2020 5:20
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