Anticardiolipin antibodies and hepatic artery thrombosis after liver transplantation

Détails

ID Serval
serval:BIB_4EA38FB91D4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Anticardiolipin antibodies and hepatic artery thrombosis after liver transplantation
Périodique
Transplantation
Auteur(s)
Pascual  M., Thadhani  R., Laposata  M., Williams  W. W., Farrell  M. L., Johnson  S. M., Tolkoff-Rubin  N., Cosimi  A. B.
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
11/1997
Peer-reviewed
Oui
Volume
64
Numéro
9
Pages
1361-4
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 15
Résumé
BACKGROUND: Hepatic artery thrombosis (HAT) remains a devastating complication after liver transplantation. Various factors have been implicated in the pathogenesis of HAT, such as clotting abnormalities, increased hematocrit, and technical complications, but the role of anticardiolipin antibodies has not been evaluated. We investigated the possible association between HAT and anticardiolipin antibodies in adult patients who underwent liver transplantation. METHODS: Seven patients with HAT after orthotopic liver transplantation, 28 liver recipients without HAT, and 35 normal blood donors were evaluated. Determination of IgM and IgG anticardiolipin antibodies was performed by enzyme-linked immunosorbent assay using pretransplant serum from all allograft recipients. Clinical information was obtained from chart review. Fisher's exact test and Wilcoxon rank sum test were used for statistical analysis, and all P-values were two-tailed. RESULTS: Overall, 22 of 35 (63%) liver recipients had a positive anticardiolipin antibody test (either IgG or IgM titer >4 SD from the normal controls). The test was positive in 7 liver recipients (100%) with HAT compared with 15 out of 28 patients (54%) without HAT (P=0.031). As compared with liver recipients without HAT, patients with HAT also tended to have a higher mean anticardiolipin titer of IgG and IgM and a lower pretransplant platelet count; however, these differences were not significant. CONCLUSIONS: Our findings indicate that anticardiolipin antibodies are frequently elevated in patients with liver failure and may contribute to the pathogenesis of HAT after liver transplantation. Other potential consequences of anticardiolipin antibodies in end-stage liver disease remain to be determined.
Mots-clé
Adult Cardiolipins/*immunology Female *Hepatic Artery Humans Immunoglobulin G/*blood Immunoglobulin M/*blood Liver Transplantation/*adverse effects Male Middle Aged Thrombosis/*blood/*etiology
Pubmed
Web of science
Création de la notice
29/01/2008 14:53
Dernière modification de la notice
20/08/2019 15:04
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