Accuracy of distinguishing between dysembryoplastic neuroepithelial tumors and other epileptogenic brain neoplasms with [(1)(1)C]methionine PET

Détails

ID Serval
serval:BIB_4EA1DDB37C1F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Accuracy of distinguishing between dysembryoplastic neuroepithelial tumors and other epileptogenic brain neoplasms with [(1)(1)C]methionine PET
Périodique
Neuro Oncol
Auteur⸱e⸱s
Rheims S., Rubi S., Bouvard S., Bernard E., Streichenberger N., Guenot M., Le Bars D., Hammers A., Ryvlin P.
ISSN
1523-5866 (Electronic)
ISSN-L
1522-8517
Statut éditorial
Publié
Date de publication
10/2014
Volume
16
Numéro
10
Pages
1417-26
Langue
anglais
Notes
Rheims, Sylvain
Rubi, Sebastia
Bouvard, Sandrine
Bernard, Emilien
Streichenberger, Nathalie
Guenot, Marc
Le Bars, Didier
Hammers, Alexander
Ryvlin, Philippe
eng
Research Support, Non-U.S. Gov't
England
Neuro Oncol. 2014 Oct;16(10):1417-26. doi: 10.1093/neuonc/nou022. Epub 2014 Mar 5.
Résumé
BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNTs) represent a prevalent cause of epileptogenic brain tumors, the natural evolution of which is much more benign than that of most gliomas. Previous studies have suggested that [(11)C]methionine positron emission tomography (MET-PET) could help to distinguish DNTs from other epileptogenic brain tumors, and hence optimize the management of patients. Here, we reassessed the diagnostic accuracy of MET-PET for the differentiation between DNT and other epileptogenic brain neoplasms in a larger population. METHODS: We conducted a retrospective study of 77 patients with focal epilepsy related to a nonrapidly progressing brain tumor on MRI who underwent MET-PET, including 52 with a definite histopathology. MET-PET data were assessed by a structured visual analysis that distinguished normal, moderately abnormal, and markedly abnormal tumor methionine uptake and by semiquantitative ratio measurements. RESULTS: Pathology showed 21 DNTs (40%), 10 gangliogliomas (19%), 19 low-grade gliomas (37%), and 2 high-grade gliomas (4%). MET-PET visual findings significantly differed among the various tumor types (P < .001), as confirmed by semiquantitative analyses (P < .001 for all calculated ratios), regardless of gadolinium enhancement on MRI. All gliomas and gangliogliomas were associated with moderately or markedly increased tumor methionine uptake, whereas 9/21 DNTs had normal methionine uptake. Receiver operating characteristics analysis of the semiquantitative ratios showed an optimal cutoff threshold that distinguished DNTs from other tumor types with 90% specificity and 89% sensitivity. CONCLUSIONS: Normal MET-PET findings in patients with an epileptogenic nonrapidly progressing brain tumor are highly suggestive of DNT, whereas a markedly increased tumor methionine uptake makes this diagnosis unlikely.
Mots-clé
Adolescent, Adult, Brain Neoplasms/complications/*diagnostic imaging, Carbon Radioisotopes, Child, Child, Preschool, Epilepsy/*complications, Female, Humans, Male, *Methionine, Middle Aged, Neoplasms, Neuroepithelial/complications/*diagnostic imaging, *Positron-Emission Tomography, Sensitivity and Specificity, Teratoma/complications/*diagnostic imaging, Young Adult, brain tumor, dysembryoplastic neuroepithelial tumor, epilepsy, methionine PET
Pubmed
Open Access
Oui
Création de la notice
29/11/2018 12:37
Dernière modification de la notice
20/08/2019 14:04
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