Galactomannan and 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Aspergillosis

Détails

Ressource 1Télécharger: jof-02-00022 (1).pdf (488.58 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_4E7659C9AD21
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Galactomannan and 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Aspergillosis
Périodique
Journal of Fungi
Auteur⸱e⸱s
Lamoth  Frédéric
ISSN
2309-608X (Electronic)
Statut éditorial
Publié
Date de publication
2016
Volume
2
Numéro
3
Pages
22
Langue
anglais
Résumé
Invasive aspergillosis (IA) is a severe complication among hematopoietic stem cell transplant recipients or patients with hematological malignancies and neutropenia following anti-cancer therapy. Moreover, IA is increasingly observed in other populations, such as solid-organ transplant recipients, patients with solid tumors or auto-immune diseases, and among intensive care unit patients. Frequent delay in diagnosis is associated with high mortality rates. Cultures from clinical specimens remain sterile in many cases and the diagnosis of IA often only relies on non-specific radiological signs in the presence of host risk factors. Tests for detection of galactomannan- (GM) and 1,3-β-d-glucan (BDG) are useful adjunctive tools for the early diagnosis of IA and may have a role in monitoring response to therapy. However, the sensitivity and specificity of these fungal biomarkers are not optimal and variations between patient populations are observed. This review discusses the role and interpretation of GM and BDG testing for the diagnosis of IA in different clinical samples (serum, bronchoalveolar lavage fluid, cerebrospinal fluid) and different groups of patients (onco-hematological patients, solid-organ transplant recipients, other patients at risk of IA).
Mots-clé
Aspergillus fumigatus, invasive aspergillosis, fungal biomarkers, galactomannan, 1,3-β-d-glucan
Open Access
Oui
Création de la notice
12/10/2016 13:13
Dernière modification de la notice
20/08/2019 15:04
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