Genes for normal sleep and sleep disorders.

Détails

ID Serval
serval:BIB_4E458DBA1640
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Genes for normal sleep and sleep disorders.
Périodique
Annals of Medicine
Auteur(s)
Tafti M., Maret S., Dauvilliers Y.
ISSN
0785-3890[print], 0785-3890[linking]
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
37
Numéro
8
Pages
580-589
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocretin/orexin gene have been found as the cause of a few sleep disorders but the possibility that other gene defects may contribute to the pathophysiology of major sleep disorders is worth in-depth investigations. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental effects, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep.
Mots-clé
Circadian Rhythm/genetics, DNA/genetics, Genetic Predisposition to Disease, Humans, Intracellular Signaling Peptides and Proteins, Neuropeptides/genetics, Nuclear Proteins/genetics, Period Circadian Proteins, Point Mutation, Protein Precursors/genetics, Sleep/genetics, Sleep Disorders/genetics, Transcription Factors/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 14:03
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