Hormonal effects of CQP 201-403, a new dopamine agonist

Détails

ID Serval
serval:BIB_4DB2DD953BAB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hormonal effects of CQP 201-403, a new dopamine agonist
Périodique
Acta Endocrinologica
Auteur(s)
Gaillard  R. C., Brownell  J.
ISSN
0001-5598 (Print)
Statut éditorial
Publié
Date de publication
11/1988
Volume
119
Numéro
3
Pages
452-8
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
CQP 201-403 is a propylergoline derivative with strong dopamine stimulant properties in animals models. It was developed in order to meet the need for a dopamine agonist compound which would offer longer action and improved tolerability. In this study, we tested CQP 201-403 m healthy male volunteers in order to assess its PRL suppression action and other hormonal effects as well as its duration of action and tolerability. Twenty-one volunteers participated in a dose-range study conducted according to a double-blind cross-over design with placebo control. The PRL suppression effect of single oral doses ranging from 0.05 mg to 0.035 mg were investigated. The duration of action of CQP 201-403 was tested in 6 other volunteers receiving a single oral dose of 0.025 mg or placebo. Blood was sampled over 48 h for PRL and GH measurements. An endocrine profile was performed in 6 volunteers receiving either 0.025 mg CQP 201-403 as a single oral dose or placebo. Blood was sampled over 8 h for measuring plasma PRL, GH, LH, FSH, TSH and cortisol. The results show strong dose-dependent PRL suppression (P less than 0.001) beginning 2 h after ingestion. PRL suppression lasted for more than 24 h and the normal sleep PRL surges were abolished. GH was transiently stimulated during the first few hours; the GH sleep profile was normal. All other hormones were not affected by the administration of CQP 201-403. Tolerability was good and no drug attributable changes in safety measures occurred.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adult Blood Pressure/drug effects Dose-Response Relationship, Drug Ergolines/*administration & dosage Follicle Stimulating Hormone/blood Growth Hormone/*blood Humans Hydrocortisone/blood Luteinizing Hormone/blood Male Prolactin/*blood Pulse/drug effects Sleep Thyrotropin/blood Time Factors
Pubmed
Web of science
Création de la notice
15/02/2008 16:58
Dernière modification de la notice
20/08/2019 14:02
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