Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing.

Détails

ID Serval
serval:BIB_4DAB28378E4A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing.
Périodique
Stroke
Auteur⸱e⸱s
Cereda C.W., Tamisier R., Manconi M., Andreotti J., Frangi J., Pifferini V., Bassetti C.L.
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
44
Numéro
4
Pages
1175-1178
Langue
anglais
Résumé
BACKGROUND AND PURPOSE: Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced a postacute ischemic event with relation to SDB, sleep disruption, and nocturnal oxygenation parameters.
METHODS: SDB was assessed by full polysomnography in patients with acute ischemic event 3 months after the admission at our stroke unit. Moderate-severe SDB was defined according to the apnea-hypopnea index as apnea-hypopnea index ≥ 20. Endothelial function and arterial stiffness were assessed by peripheral arterial tonometry using Endo-PAT 2000.
RESULTS: Thirty-seven patients were included. The augmentation index was significantly different between patients with apnea-hypopnea index <20 and apnea-hypopnea index ≥ 20 (22.4 ± 15.6% versus 34.6 ± 21.6%; P=0.042), whereas reactive hyperemia index level was not (2.02 ± 0.65 versus 2.31 ± 0.61; P=0.127). Patients with apnea-hypopnea index ≥ 20 showed an increased risk for arterial stiffness (odds ratio, 5.98 [95% CI, 1.11-41.72]) even when controlling for age, sex, body mass index, hypertension, and diabetes mellitus. The augmentation index was correlated with the arousal index (P=0.010) and with mean O2 saturation (P = 0.043).
CONCLUSIONS: Poststroke patients with moderate-severe SDB were more prone to have increased arterial stiffness, although we did not find significant differences in endothelial function. Arterial stiffness also correlated with sleep disruption (arousal index) and mean O2 saturation.
Mots-clé
Adult, Aged, Body Mass Index, Endothelium, Vascular/pathology, Female, Humans, Ischemia/diagnosis, Ischemia/therapy, Ischemic Attack, Transient/diagnosis, Ischemic Attack, Transient/therapy, Male, Middle Aged, Odds Ratio, Oxygen/metabolism, Polysomnography, Prospective Studies, Risk, Risk Factors, Sleep Apnea Syndromes/physiopathology, Stroke/diagnosis, Stroke/physiopathology, Vascular Stiffness
Pubmed
Open Access
Oui
Création de la notice
17/03/2016 10:15
Dernière modification de la notice
20/08/2019 15:02
Données d'usage