Nano- and neurotoxicology: an emerging discipline

Détails

Ressource 1Télécharger: 2018_Bencsick_Nano_ProgrNeurobiol_postprint_final.pdf (1547.37 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_4DAAFC86E4D2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Nano- and neurotoxicology: an emerging discipline
Périodique
Progress in Neurobiology
Auteur(s)
Bencsik Anna, Lestaevel Philippe, Guseva Canu Irina
ISSN
1873-5118 (Electronic)
ISSN-L
0301-0082
Statut éditorial
Publié
Date de publication
01/2018
Peer-reviewed
Oui
Volume
160
Pages
45-63
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The present critical review analyzes the question of how nanoparticles from continuously growing industrial production and use of nanomaterials may impact human brain health. Available evidence suggests incomplete effectiveness of protective barriers of the brain against nanoparticles translocation to the brain. This raises concerns of potential effects of manufactured nanoparticles on brain functions, given that nanoparticle's potential to induce oxidative stress, inflammation, death by apoptosis, or changes in the level of expression of certain neurotransmitters. Most concerns have not been studied sufficiently and many questions are still open: Are the findings in animals transposable to humans? What happens when exposure is chronic or protracted? What happens to the developing brain when exposure occurs in utero? Are some nanoparticles more deleterious, given their ability to alter protein conformations and aggregation? Aside from developments in nanomedicine, the evidence already available fully justifies the need to specifically evaluate the interactions between nanoparticles and the nervous system. The available data clearly indicates the need for original dedicated experimental models and tools for neurotoxicological research on the one hand, and the need for epidemiological studies of neurodegenerative diseases in manufactured nanoparticle-exposed populations, on the other. A combination of nanotoxicology with neurology in a novel discipline, with its specific tools and methods of investigation, should enable answering still unresolved questions.
Mots-clé
Animals, Humans, Nanostructures/toxicity, Neurotoxicity Syndromes/etiology, Neurotoxicity Syndromes/physiopathology, Neurotoxins/toxicity, Toxicology, Barriers, Brain, Chronic exposure, Epidemiological studies, Nanomaterials, Neurodegenerative diseases, Toxicity, Translocation
Pubmed
Web of science
Création de la notice
16/01/2018 12:41
Dernière modification de la notice
20/08/2019 14:02
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