Effects of smoking and physical exercise on platelet free cytosolic calcium in healthy normotensive volunteers.

Détails

ID Serval
serval:BIB_4D9B0345E911
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of smoking and physical exercise on platelet free cytosolic calcium in healthy normotensive volunteers.
Périodique
Journal of hypertension
Auteur(s)
Mooser V., Burnier M., Nussberger J., Juillerat L., Waeber B., Brunner H.R.
ISSN
0263-6352
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
7
Numéro
3
Pages
211-6
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Platelet free cytosolic calcium (PFCC) was measured in 21 healthy volunteers before and after cigarette smoking or physical exercise. The aim was to investigate whether acute blood pressure changes and increases in circulating levels of catecholamines and vasopressin modify PFCC. PFCC was determined using the Quin-2 method. Following cigarette smoking, significant increases in blood pressure, heart rate, plasma epinephrine (35 +/- 18 pg/ml before versus 51 +/- 31 pg/ml after smoking, P less than 0.05, mean +/- s.d.) and vasopressin levels (0.8 +/- 0.3 pg/ml before and 4.2 +/- 4.1 pg/ml after smoking, P less than 0.001) were observed. However, despite these acute hormonal and hemodynamic changes, PFCC remained stable at 156 +/- 55 nmol/l prior to the study and 157 +/- 29 nmol/l and 156 +/- 38 nmol/l at 20 and 80 min post-smoking, respectively. Acute physical exercise led to an increase in heart rate and systolic blood pressure but to a decrease in diastolic pressure. Moreover, a marked increase in plasma norepinephrine levels was observed after exercise (213 +/- 71 pg/ml before versus 747 +/- 501 pg/ml after exercise, P +/- 0.001). Again, PFCC was stable at 185 +/- 56 nmol/l at baseline versus 188 +/- 51 nmol/l at 20 min and 155 +/- 26 nmol/l at 80 min after exercise. These results therefore demonstrate that PFCC is not influenced acutely either by blood pressure increases, or by elevations in circulating catecholamine and vasopressin concentrations.
Mots-clé
Adult, Blood Platelets, Blood Pressure, Calcium, Cytosol, Epinephrine, Exercise, Heart Rate, Humans, Male, Norepinephrine, Smoking, Vasopressins
Pubmed
Web of science
Création de la notice
25/01/2008 12:56
Dernière modification de la notice
20/08/2019 14:02
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