The function of natural killer cells: education, reminders and some good memories.

Détails

ID Serval
serval:BIB_4D83C8221835
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The function of natural killer cells: education, reminders and some good memories.
Périodique
Current Opinion in Immunology
Auteur(s)
Held W., Kijima M., Angelov G., Bessoles S.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2011
Volume
23
Numéro
2
Pages
228-233
Langue
anglais
Résumé
The effector response of natural killer (NK) cells is determined by opposing signals received through activating and inhibitory receptors. A process termed NK cell education, which is guided by the recognition of Major Histocompatibility Complex class I (MHC-I) molecules, determines how efficiently activating receptors respond to stimulation. This ensures NK cell tolerance to healthy tissues while allowing robust responses to diseased host cells. It was thought that NK cells are educated during their development in the bone marrow and that education fixes the NK cells' functional properties. However, recent findings suggest that the function of mature peripheral NK cells can adapt to changes in their environment and that the persistent exposure to normal-self is essential to maintain NK cell reactivity. Notwithstanding, NK cell stimulation in the context of inflammation can stably improve the functional properties of NK cells.
Mots-clé
Adaptive Immunity, Cell Differentiation, Histocompatibility Antigens Class I/immunology, Humans, Immune Tolerance, Immunologic Memory, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology
Pubmed
Web of science
Création de la notice
16/02/2012 15:05
Dernière modification de la notice
20/08/2019 14:02
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