Reasons for discontinuation of recommended therapies according to the patients after acute coronary syndromes.

Détails

ID Serval
serval:BIB_4D7ED76266C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Reasons for discontinuation of recommended therapies according to the patients after acute coronary syndromes.
Périodique
European Journal of Internal Medicine
Auteur(s)
Gencer B., Rodondi N., Auer R., Räber L., Klingenberg R., Nanchen D., Carballo D., Vogt P., Carballo S., Meyer P., Matter C.M., Windecker S., Lüscher T.F., Mach F.
ISSN
1879-0828 (Electronic)
ISSN-L
0953-6205
Statut éditorial
Publié
Date de publication
01/2015
Peer-reviewed
Oui
Volume
26
Numéro
1
Pages
56-62
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: The prescription of recommended medical therapies is a key factor to improve prognosis after acute coronary syndromes (ACS). However, reasons for cardiovascular therapies discontinuation after hospital discharge are poorly reported in previous studies.
METHODS: We enrolled 3055 consecutive patients hospitalized with a main diagnosis of ACS in four Swiss university hospitals with a prospective one-year follow-up. We assessed the self-reported use of recommended therapies and the reasons for medication discontinuation according to the patient interview performed at one-year follow-up.
RESULTS: 3014 (99.3%) patients were discharged with aspirin, 2983 (98.4%) with statin, 2464 (81.2%) with beta-blocker, 2738 (90.3%) with ACE inhibitors/ARB and 2597 (100%) with P2Y12 inhibitors if treated with coronary stent. At the one-year follow-up, the discontinuation percentages were 2.9% for aspirin, 6.6% for statin, 11.6% for beta-blocker, 15.1% for ACE inhibitor/ARB and 17.8% for P2Y12 inhibitors. Most patients reported having discontinued their medication based on their physicians' decision: 64 (2.1%) for aspirin, 82 (2.7%) for statin, 212 (8.6%) for beta-blocker, 251 (9.1% for ACE inhibitor/ARB) and 293 (11.4%) for P2Y12 inhibitors, while side effect, perception that medication was unnecessary and medication costs were uncommon reported reasons (<2%) according to the patients.
CONCLUSIONS: Discontinuation of recommended therapies after ACS differs according the class of medication with the lowest percentages for aspirin. According to patients, most stopped their cardiovascular medication based on their physician's decision, while spontaneous discontinuation was infrequent.
Pubmed
Web of science
Création de la notice
12/02/2015 8:45
Dernière modification de la notice
20/08/2019 14:02
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