Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences.

Détails

ID Serval
serval:BIB_4D71EE807B33
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences.
Périodique
Virology
Auteur(s)
Reiss C., Niedobitek G., Hör S., Lisner R., Friedrich U., Bodemer W., Biesinger B.
ISSN
0042-6822
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
294
Numéro
1
Pages
31-46
Langue
anglais
Résumé
Efficiency of lymphoma induction by herpesvirus saimiri (HVS) isolates correlates with the genetically defined viral subgroups A, B, and C. To compare subgroup-specific effects, highly susceptible tamarins were infected with HVS strain A-11, B-SMHI, or C-488. All animals developed T-cell lymphomas indistinguishable with respect to clinical, pathological, and virological parameters. Ex vivo T-cell lines were established readily from the HVS C-488 animal, less efficiently in the presence of HVS A-11, and from only a single HVS B-SMHI sample. These cultivated cells revealed strain-specific biochemical characteristics. HVS A-11 strongly induced the expression of tyrosine kinase Lyn. HVS C-488 led to the activation of STAT3, which is most likely linked to the association of virus-encoded Tip with tyrosine kinase Lck. The lack of these activities in HVS B-SMHI-transformed cells may correlate with the reduced oncogenic phenotype of this virus in species other than tamarins.
Mots-clé
Animals, Cell Line, Transformed, DNA-Binding Proteins/metabolism, Herpesviridae Infections/pathology, Herpesviridae Infections/virology, Herpesvirus 2, Saimiriine/classification, Herpesvirus 2, Saimiriine/pathogenicity, Lymphoma, T-Cell/pathology, Lymphoma, T-Cell/virology, Oncogene Proteins, Viral/genetics, Oncogene Proteins, Viral/metabolism, Phosphoproteins/metabolism, Phosphorylation, Protein-Tyrosine Kinases/metabolism, STAT3 Transcription Factor, Saguinus, T-Lymphocytes/virology, Trans-Activators/metabolism, Tumor Cells, Cultured, Tumor Virus Infections/pathology, Tumor Virus Infections/virology, Viral Proteins/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/10/2008 11:00
Dernière modification de la notice
20/08/2019 15:02
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