Effective stiffening of DNA due to nematic ordering causes DNA molecules packed in phage capsids to preferentially form torus knots.

Détails

Ressource 1Télécharger: BIB_4D5FAD702911.P001.pdf (2116.86 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_4D5FAD702911
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effective stiffening of DNA due to nematic ordering causes DNA molecules packed in phage capsids to preferentially form torus knots.
Périodique
Nucleic Acids Research
Auteur⸱e⸱s
Reith D., Cifra P., Stasiak A., Virnau P.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2012
Volume
40
Numéro
11
Pages
5129-5137
Langue
anglais
Résumé
Observation that DNA molecules in bacteriophage capsids preferentially form torus type of knots provided a sensitive gauge to evaluate various models of DNA arrangement in phage heads. Only models resulting in a preponderance of torus knots could be considered as close to reality. Recent studies revealed that experimentally observed enrichment of torus knots can be qualitatively reproduced in numerical simulations that include a potential inducing nematic arrangement of tightly packed DNA molecules within phage capsids. Here, we investigate what aspects of the nematic arrangement are crucial for inducing formation of torus knots. Our results indicate that the effective stiffening of DNA by the nematic arrangement not only promotes knotting in general but is also the decisive factor in promoting formation of DNA torus knots in phage capsids.
Mots-clé
Bacteriophages/genetics, Capsid/chemistry, DNA, Viral/chemistry, Models, Molecular, Virus Assembly
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/07/2012 19:08
Dernière modification de la notice
20/08/2019 15:02
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