Development of a retrospective job exposure matrix for PCB-exposed workers in capacitor manufacturing

Détails

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Etat: Supprimée
Version: de l'auteur
ID Serval
serval:BIB_4D1EB8C4912C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Development of a retrospective job exposure matrix for PCB-exposed workers in capacitor manufacturing
Périodique
Journal of Occupational Health
Auteur(s)
Hopf Nancy B., Waters Martha A., Ruder Avima M., Prince Mary M.
ISSN
1348-9585 (Electronic)
ISSN-L
1341-9145
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
52
Numéro
4
Pages
199-208
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers (n=12,605) (1938-1977).
A detailed exposure assessment for this plant was based on a number of exposure determinants (proximity, degree of contact with PCBs, temperature, ventilation, process control, job mobility). The intensity and frequency of PCB exposures by job for both inhalation and dermal exposures, and additional chemical exposures were reviewed. The JEM was developed in nine steps: (1) all unique jobs (n=1,684) were assessed using (2) defined PCB exposure determinants; (3) the exposure determinants were used to develop exposure profiles; (4) similar exposure profiles were combined into categories having similar PCB exposures; (5) qualitative intensity (high-medium-low-baseline) and frequency (continuous-intermittent) ratings were developed, and (6) used to qualitatively rate inhalation and dermal exposure separately for each category; (7) quantitative intensity ratings based on available air concentrations were developed for inhalation and dermal exposures based on equal importance of both routes of exposure; (8) adjustments were made for overall exposure, and (9) for each category the product of intensity and frequency was calculated, and exposure in the earlier era was weighted.
A period-specific JEM modified for two eras of stable PCB exposure conditions.
These exposure estimates, derived from a systematic and rigorous use of the exposure determinant data, lead to cumulative PCB exposure-response relationships in the epidemiological cancer mortality and incidence studies of this cohort.

Mots-clé
Dose-Response Relationship, Drug, Environmental Pollutants/poisoning, Epidemiologic Research Design, Estrogen Antagonists/poisoning, Female, Humans, Male, Massachusetts/epidemiology, Occupational Diseases/chemically induced, Occupational Diseases/epidemiology, Occupational Exposure/analysis, Occupational Exposure/statistics & numerical data, Polychlorinated Biphenyls/poisoning, Retrospective Studies
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/01/2011 9:57
Dernière modification de la notice
20/08/2019 14:01
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