Vitamin D status, functional decline, and mortality in peripheral artery disease.
Détails
ID Serval
serval:BIB_4D1A736970E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Vitamin D status, functional decline, and mortality in peripheral artery disease.
Périodique
Vascular medicine
ISSN
1477-0377 (Electronic)
ISSN-L
1358-863X
Statut éditorial
Publié
Date de publication
02/2014
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
18-26
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Résumé
Associations of vitamin D levels with prospectively measured functional decline and mortality in people with lower extremity peripheral artery disease (PAD) are unknown. We determined whether lower baseline vitamin D levels are associated with a faster decline in functional performance and higher mortality among people with and without PAD. A total of 658 participants (395 with PAD) underwent baseline measurement of 25-hydroxyvitamin D (DiaSorin radioimmunoassay), a 6-minute walk test, 4-meter walking velocity and the Short Physical Performance Battery (SPPB), and were followed annually for up to 4 years. Analyses were adjusted for age, sex, race, body mass index, comorbidities, the ankle-brachial index, and other confounders. Among participants with PAD, lower baseline vitamin D levels were associated with a faster decline in the 6-minute walk (vitamin D < 30 nmol/L: -70.0 feet/year; vitamin D 30 to < 50 nmol/L: -72.3 feet/year; vitamin D 50 to < 75 nmol/L: -35.5 feet/year; vitamin D 75 to < 120 nmol/L: -35.9 feet/year; p trend=0.012). PAD participants with vitamin D < 30 nmol/L had a faster decline in the SPPB and 6-minute walk compared to those with levels of 50 to < 75 (p=0.034 and p=0.04, respectively). Among participants without PAD, lower vitamin D was associated with a faster decline in the fast 4-meter walking velocity (p trend=0.003). There were no significant associations of baseline vitamin D levels with all-cause or cardiovascular disease mortality in PAD or non-PAD participants. In conclusion, among individuals with and without PAD, low vitamin D status was associated with a faster decline in some measures of functional performance but was not related to mortality.
Mots-clé
Aged, Aged, 80 and over, Ankle Brachial Index, Body Mass Index, Exercise/physiology, Exercise Test, Female, Humans, Intermittent Claudication/metabolism, Lower Extremity/physiopathology, Male, Middle Aged, Peripheral Arterial Disease/metabolism, Peripheral Arterial Disease/mortality, Peripheral Arterial Disease/physiopathology, Vitamin D/metabolism, Walking, exercise, intermittent claudication, peripheral arterial disease, peripheral vascular diseases, walking
Pubmed
Web of science
Création de la notice
27/12/2020 23:46
Dernière modification de la notice
28/12/2020 7:26