Vitamin D status, functional decline, and mortality in peripheral artery disease.

Détails

ID Serval
serval:BIB_4D1A736970E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vitamin D status, functional decline, and mortality in peripheral artery disease.
Périodique
Vascular medicine
Auteur(s)
McDermott M.M., Liu K., Ferrucci L., Tian L., Guralnik J., Kopp P., Van Horn L., Liao Y., Green D., Kibbe M., Sufit R., Zhao L., Criqui M.H.
ISSN
1477-0377 (Electronic)
ISSN-L
1358-863X
Statut éditorial
Publié
Date de publication
02/2014
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
18-26
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
Associations of vitamin D levels with prospectively measured functional decline and mortality in people with lower extremity peripheral artery disease (PAD) are unknown. We determined whether lower baseline vitamin D levels are associated with a faster decline in functional performance and higher mortality among people with and without PAD. A total of 658 participants (395 with PAD) underwent baseline measurement of 25-hydroxyvitamin D (DiaSorin radioimmunoassay), a 6-minute walk test, 4-meter walking velocity and the Short Physical Performance Battery (SPPB), and were followed annually for up to 4 years. Analyses were adjusted for age, sex, race, body mass index, comorbidities, the ankle-brachial index, and other confounders. Among participants with PAD, lower baseline vitamin D levels were associated with a faster decline in the 6-minute walk (vitamin D < 30 nmol/L: -70.0 feet/year; vitamin D 30 to < 50 nmol/L: -72.3 feet/year; vitamin D 50 to < 75 nmol/L: -35.5 feet/year; vitamin D 75 to < 120 nmol/L: -35.9 feet/year; p trend=0.012). PAD participants with vitamin D < 30 nmol/L had a faster decline in the SPPB and 6-minute walk compared to those with levels of 50 to < 75 (p=0.034 and p=0.04, respectively). Among participants without PAD, lower vitamin D was associated with a faster decline in the fast 4-meter walking velocity (p trend=0.003). There were no significant associations of baseline vitamin D levels with all-cause or cardiovascular disease mortality in PAD or non-PAD participants. In conclusion, among individuals with and without PAD, low vitamin D status was associated with a faster decline in some measures of functional performance but was not related to mortality.
Mots-clé
Aged, Aged, 80 and over, Ankle Brachial Index, Body Mass Index, Exercise/physiology, Exercise Test, Female, Humans, Intermittent Claudication/metabolism, Lower Extremity/physiopathology, Male, Middle Aged, Peripheral Arterial Disease/metabolism, Peripheral Arterial Disease/mortality, Peripheral Arterial Disease/physiopathology, Vitamin D/metabolism, Walking, exercise, intermittent claudication, peripheral arterial disease, peripheral vascular diseases, walking
Pubmed
Web of science
Création de la notice
27/12/2020 22:46
Dernière modification de la notice
28/12/2020 6:26
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