Adaptive radiotherapy for head and neck cancer.

Détails

ID Serval
serval:BIB_4D054507CBEA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Adaptive radiotherapy for head and neck cancer.
Périodique
Acta oncologica
Auteur(s)
Castelli J., Simon A., Lafond C., Perichon N., Rigaud B., Chajon E., De Bari B., Ozsahin M., Bourhis J., de Crevoisier R.
ISSN
1651-226X (Electronic)
ISSN-L
0284-186X
Statut éditorial
Publié
Date de publication
10/2018
Peer-reviewed
Oui
Volume
57
Numéro
10
Pages
1284-1292
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Large anatomical variations can be observed during the treatment course intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), leading to potential dose variations. Adaptive radiotherapy (ART) uses one or several replanning sessions to correct these variations and thus optimize the delivered dose distribution to the daily anatomy of the patient. This review, which is focused on ART in the HNC, aims to identify the various strategies of ART and to estimate the dosimetric and clinical benefits of these strategies.
We performed an electronic search of articles published in PubMed/MEDLINE and Science Direct from January 2005 to December 2016. Among a total of 134 articles assessed for eligibility, 29 articles were ultimately retained for the review. Eighteen studies evaluated dosimetric variations without ART, and 11 studies reported the benefits of ART.
Eight in silico studies tested a number of replanning sessions, ranging from 1 to 6, aiming primarily to reduce the dose to the parotid glands. The optimal timing for replanning appears to be early during the first two weeks of treatment. Compared to standard IMRT, ART decreases the mean dose to the parotid gland from 0.6 to 6 Gy and the maximum dose to the spinal cord from 0.1 to 4 Gy while improving target coverage and homogeneity in most studies. Only five studies reported the clinical results of ART, and three of those studies included a non-randomized comparison with standard IMRT. These studies suggest a benefit of ART in regard to decreasing xerostomia, increasing quality of life, and increasing local control. Patients with the largest early anatomical and dose variations are the best candidates for ART.
ART may decrease toxicity and improve local control for locally advanced HNC. However, randomized trials are necessary to demonstrate the benefit of ART before using the technique in routine practice.
Mots-clé
Head and Neck Neoplasms/mortality, Head and Neck Neoplasms/radiotherapy, Humans, Organs at Risk, Parotid Gland/radiation effects, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted/methods, Radiotherapy, Intensity-Modulated, Spinal Cord/radiation effects
Pubmed
Web of science
Création de la notice
16/10/2018 10:07
Dernière modification de la notice
20/08/2019 14:01
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