Le point sur les antibiotiques beta-lactames. [Focus on beta-lactam antibiotics]

Détails

ID Serval
serval:BIB_4C1865E675C2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Le point sur les antibiotiques beta-lactames. [Focus on beta-lactam antibiotics]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur⸱e⸱s
Cometta  A., Glauser  M. P.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1988
Volume
118
Numéro
49
Pages
1817-22
Notes
English Abstract
Journal Article
Review --- Old month value: Dec 10
Résumé
The beta-lactams are mainly active on the bacterial cell wall. Although it was long claimed that their clinical efficacy was due to the bactericidal effect observed in vitro, it is now demonstrated that this effect cannot be the sole explanation for the therapeutic successes noted with these antibiotics in clinical situations. Several effects other than bactericidal are observed at subinhibitory concentrations and allow a better understanding of the activity of the beta-lactams. These are, among others, inhibition of bacterial growth, the post-antibiotic effect, the morphological effect, loss of virulent factors and decrease of adherence. --Following recent developments in the field of the beta-lactams, the new antibiotics exhibit a major broadening of their microbiological spectrum that in some cases allows simplification of antibiotic therapy: in some clinical situations monotherapy can be used instead of a combination. Some antibiotics have very good pharmacokinetic properties, allowing once-a-day dosage and outpatient treatment. --Finally, adverse drug effects such as neutropenia, hitherto considered infrequent, have been recognized more often. Explanation of their physiopathological mechanisms could favour the development of less toxic antibiotics.
Mots-clé
Animals Anti-Bacterial Agents/*pharmacology Bacteria/*drug effects/growth & development Bacterial Adhesion/drug effects Cell Wall/drug effects Humans Phagocytosis/drug effects beta-Lactams
Pubmed
Web of science
Création de la notice
25/01/2008 14:31
Dernière modification de la notice
20/08/2019 15:00
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