White Matter Changes in Bipolar Disorder, Alzheimer Disease, and Mild Cognitive Impairment: New Insights from DTI.

Détails

Ressource 1Télécharger: BIB_4BBA5F137544.P001.pdf (995.83 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_4BBA5F137544
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
White Matter Changes in Bipolar Disorder, Alzheimer Disease, and Mild Cognitive Impairment: New Insights from DTI.
Périodique
Journal of Aging Research
Auteur(s)
Xekardaki A., Giannakopoulos P., Haller S.
ISSN
2090-2212 (Electronic)
ISSN-L
2090-2204
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
2011
Pages
286564
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Neuropathological and neuroimaging studies have reported significant changes in white matter in psychiatric and neurodegenerative diseases. Diffusion tensor imaging (DTI), a recently developed technique, enables the detection of microstructural changes in white matter. It is a noninvasive in vivo technique that assesses water molecules' diffusion in brain tissues. The most commonly used parameters are axial and radial diffusivity reflecting diffusion along and perpendicular to the axons, as well as mean diffusivity and fractional anisotropy representing global diffusion. Although the combination of these parameters provides valuable information about the integrity of brain circuits, their physiological meaning still remains controversial. After reviewing the basic principles of DTI, we report on recent contributions that used this technique to explore subtle structural changes in white matter occurring in elderly patients with bipolar disorder and Alzheimer disease.
Pubmed
Open Access
Oui
Création de la notice
23/12/2011 15:50
Dernière modification de la notice
20/08/2019 14:59
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