Neurological and pulmonary adverse effects of subcutaneous methotrexate therapy.

Détails

ID Serval
serval:BIB_4BB7A3F17C1B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Neurological and pulmonary adverse effects of subcutaneous methotrexate therapy.
Périodique
Scandinavian Journal of Rheumatology
Auteur⸱e⸱s
Sommer W.H., Ganiere V., Gachoud D., Keta A., Abou-Hajar A., Dudler J., Aujesky D.
ISSN
0300-9742
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
37
Numéro
4
Pages
306-309
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
We report the case of a patient receiving subcutaneous methotrexate (MTX) treatment for rheumatoid arthritis (RA) who developed a complex pattern of neurological and pulmonary symptoms. Fluctuant dysarthria, magnetic gait, weakness and dysmetria of the lower limbs, as well as symptoms and signs consistent with a diagnosis of pneumonitis started within 6 weeks of initiating MTX treatment and slowly resolved after its discontinuation. This case highlights the fact that even the relatively low doses of MTX in the therapy of RA can produce neurotoxicity, which can become manifest in a broad range of symptoms.
Mots-clé
Aged, 80 and over, Arthritis, Rheumatoid, Female, Humans, Immunosuppressive Agents, Injections, Subcutaneous, Methotrexate, Neurotoxicity Syndromes, Pneumonia
Pubmed
Web of science
Création de la notice
02/03/2009 15:22
Dernière modification de la notice
20/08/2019 13:59
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