Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes.

Détails

ID Serval
serval:BIB_4B7C28C769A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes.
Périodique
Diabetologia
Auteur(s)
Pinizzotto M., Castillo E., Fiaux M., Temler E., Gaillard R.C., Ruiz J.
ISSN
0012-186X
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
44
Numéro
1
Pages
104-7
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
AIMS/HYPOTHESIS: Paraoxonase is a member of a multigene family of three genes. Paraoxonase2 gene polymorphisms have been associated with coronary heart disease in non-diabetic patients and with an increased fasting glycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus. We tested the hypothesis of whether paraoxonase1 and paraoxonase2 polymorphisms were associated with diabetic nephropathy. METHODS: Our case-control study of 299 Swiss patients with Type II diabetes included 147 patients with confirmed diabetic nephropathy. RESULTS: In univariate analyses the two paraoxonase2 polymorphisms were associated with diabetic nephropathy. When subjected to multivariate analyses, both paraoxonase2 polymorphisms remained statistically associated with diabetic nephropathy independent of traditional risk factors (paraoxonase2-148: OR = 2.53, p = 0.003; paraoxonase2-311: OR = 2.67, p = 0.002). In addition, BMI interacted with paraoxonase2 polymorphisms as a risk factor of nephropathy. CONCLUSIONS/INTERPRETATION: The paraoxonase2 gene polymorphisms were significantly associated with diabetic nephropathy independent of traditional risk factors in Type II diabetic patients. The susceptibility to diabetic nephropathy was intensified by the degree of obesity. Pathophysiological pathways should be investigated and could be involved in insulin resistance or lipids metabolism or both.
Mots-clé
Aryldialkylphosphatase, Body Mass Index, Case-Control Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Esterases, Female, Homozygote, Humans, Linkage Disequilibrium, Logistic Models, Male, Multivariate Analysis, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
20/08/2019 14:59
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