Effet du Naftidrofuryl (Praxilene) sur le flux sanguin de la tete du nerf optique du patient glaucomateux. [Effect of naftidrofuryl (praxilene) on optic nerve head blood flow in the patient with glaucoma]
Détails
ID Serval
serval:BIB_4B6E1D0F1C34
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effet du Naftidrofuryl (Praxilene) sur le flux sanguin de la tete du nerf optique du patient glaucomateux. [Effect of naftidrofuryl (praxilene) on optic nerve head blood flow in the patient with glaucoma]
Périodique
Klinische Monatsblatter fur Augenheilkunde
ISSN
0023-2165 (Print)
Statut éditorial
Publié
Date de publication
05/1999
Volume
214
Numéro
5
Pages
260-2
Notes
English Abstract
Journal Article --- Old month value: May
Journal Article --- Old month value: May
Résumé
PURPOSE: To evaluate the effects of an S2 specific antiserotonine agent (Naftidrofuryl) on the optic nerve head blood flow in glaucomatous patient. PATIENTS AND METHOD: 11 glaucomatous subjects were enrolled in the study. After administration of 200 mg naftidrofuryl twice daily for 7 days: values of optic nerve head blood flow (Fonh), velocity and volume were recorded in the temporal rim and cup of the optic nerve head. Blood flow measurements were performed by laser doppler flow-metry at day 0 and day 7 before and one and two hours after drug administration. RESULTS: Our study showed a significant improvement of perfusion pressure (p = 0.02) at day 7 and an increase of mean ophthalmique artery pressure (p = 0.03). DISCUSSION: Our preliminary results on a small number of patients and a short follow-up indicate that the use of naftidrofuryl may enhance optic nerve head blood flow in glaucomatous patients. Further studies may confirm these results.
Mots-clé
Aged
Aged, 80 and over
Blood Flow Velocity/drug effects
Blood Pressure/drug effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Glaucoma/*drug therapy/physiopathology
Glaucoma, Open-Angle/*drug therapy/physiopathology
Humans
Intraocular Pressure/drug effects
Laser-Doppler Flowmetry
Male
Middle Aged
Nafronyl/*administration & dosage/adverse effects
Optic Disk/*blood supply
Serotonin Antagonists/*administration & dosage/adverse effects
Vasodilator Agents/*administration & dosage/adverse effects
Pubmed
Web of science
Création de la notice
28/01/2008 13:49
Dernière modification de la notice
20/08/2019 14:59