A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging.

Détails

ID Serval
serval:BIB_4B4127A2825D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging.
Périodique
Neuroimage
Auteur(s)
Hutton C., Draganski B., Ashburner J., Weiskopf N.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
48
Numéro
2
Pages
371-380
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
The morphology of cortical grey matter is commonly assessed using T1-weighted MRI together with automated computerised methods such as voxel-based morphometry (VBM) and cortical thickness measures. In the presented study we investigate how grey matter changes identified using voxel-based cortical thickness (VBCT) measures compare with local grey matter volume changes identified using VBM. We use data from a healthy aging population to perform the comparison, focusing on brain regions where age-related changes have been observed in previous studies. Our results show that overall, in healthy aging, VBCT and VBM yield very consistent results but VBCT provides a more sensitive measure of age-associated decline in grey matter compared with VBM. Our findings suggest that while VBCT selectively investigates cortical thickness, VBM provides a mixed measure of grey matter including cortical surface area or cortical folding, as well as cortical thickness. We therefore propose that used together, these techniques can separate the underlying grey matter changes, highlighting the utility of combining these complementary methods.
Mots-clé
Adult, Aging/pathology, Cerebral Cortex/pathology, Female, Humans, Image Processing, Computer-Assisted/methods, Imaging, Three-Dimensional, Linear Models, Magnetic Resonance Imaging/methods, Male, Middle Aged, Organ Size, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/01/2013 18:51
Dernière modification de la notice
20/08/2019 14:59
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