CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL.

Détails

Ressource 1Télécharger: 5_27923834_Postprint.pdf (1891.91 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_4B32A87479EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL.
Périodique
Cancer research
Auteur(s)
Manfroi B., McKee T., Mayol J.F., Tabruyn S., Moret S., Villiers C., Righini C., Dyer M., Callanan M., Schneider P., Tzankov A., Matthes T., Sturm N., Huard B.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
01/03/2017
Peer-reviewed
Oui
Volume
77
Numéro
5
Pages
1097-1107
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Tumor-infiltrating neutrophils have been implicated in malignant development and progression, but mechanisms are ill defined. Neutrophils produce a proliferation-inducing ligand APRIL/TNFSF13, a factor that promotes development of tumors from diverse origins, including diffuse large B-cell lymphoma (DLBCL). High APRIL expression in DLBCL correlates with reduced patient survival, but the pathway(s) dictating APRIL expression are not known. Here, we show that all blood neutrophils constitutively secrete APRIL, and inflammation-associated stimuli, such as TNF, further upregulate APRIL. In a significant fraction of DLBCL patients, tumor cells constitutively produced the ELC-CXC chemokine CXCL-8 (IL8), enabling them to recruit APRIL-producing blood neutrophils. CXCL-8 production in DLBCL was unrelated to the cell of origin, as APRIL-producing neutrophils infiltrated CXCL-8(+) DLBCL from both germinal center (GC) and non-GC subtypes. Rather, CXCL-8 production implied events affecting DNA methylation and acetylation. Overall, our results showed that chemokine-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression. Cancer Res; 77(5); 1097-107. ©2016 AACR.

Mots-clé
Animals, Humans, Interleukin-8/biosynthesis, Interleukin-8/immunology, Ligands, Lymphoma, Large B-Cell, Diffuse/genetics, Lymphoma, Large B-Cell, Diffuse/immunology, Lymphoma, Large B-Cell, Diffuse/metabolism, Lymphoma, Large B-Cell, Diffuse/pathology, Mice, Neutrophils/immunology, Neutrophils/metabolism, Neutrophils/pathology, Tumor Microenvironment/immunology, Tumor Necrosis Factor Ligand Superfamily Member 13/biosynthesis, Tumor Necrosis Factor Ligand Superfamily Member 13/genetics, Tumor Necrosis Factor Ligand Superfamily Member 13/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/12/2016 19:19
Dernière modification de la notice
20/08/2019 14:59
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