Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome

Détails

ID Serval
serval:BIB_4A7EFC83C376
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome
Périodique
Chest
Auteur⸱e⸱s
Spragg  R. G., Gilliard  N., Richman  P., Smith  R. M., Hite  R. D., Pappert  D., Robertson  B., Curstedt  T., Strayer  D.
ISSN
0012-3692 (Print)
Statut éditorial
Publié
Date de publication
01/1994
Volume
105
Numéro
1
Pages
195-202
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Résumé
In an attempt to restore functional surfactant to the lungs of patients with the adult respiratory distress syndrome (ARDS), we have treated six patients within the first 2 days of the onset of ARDS with a single dose of hydrophobic components of porcine surfactant. Surfactant (4 g in 50 ml) delivered via a bronchoscope in aliquots to each of the lobar bronchi was well tolerated and caused a modest transient improvement in gas exchange. No significant changes in chest radiograph or lung compliance were detected. Analysis of bronchoalveolar lavage (BAL) fluid showed no change in albumin, alpha-1-proteinase inhibitor specific activity, or cell count. Bronchoalveolar lavage phospholipid concentrations were elevated 3 h after surfactant administration relative to preadministration levels and fell by 24 h. In addition, in two patients we found reduced inhibition of surfactant function in BAL after surfactant replacement. These observations suggest a role for surfactant replacement in the treatment of patients with ARDS and support the need for continuing investigation.
Mots-clé
Adult Animals Antigen-Antibody Complex/analysis Bronchoalveolar Lavage Fluid/chemistry Bronchoscopy Feasibility Studies Female Humans Leukocyte Elastase Male Middle Aged Oxygen/blood Pancreatic Elastase/analysis Placebos Pulmonary Gas Exchange/drug effects/physiology Pulmonary Surfactants/administration & dosage/analysis/*therapeutic use Respiratory Distress Syndrome, Adult/blood/*drug therapy/physiopathology Safety Swine alpha 1-Antitrypsin/analysis
Pubmed
Web of science
Création de la notice
28/01/2008 10:50
Dernière modification de la notice
20/08/2019 13:58
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