Dominant role of the niche in melanocyte stem-cell fate determination

Détails

ID Serval
serval:BIB_4A71602D6B66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dominant role of the niche in melanocyte stem-cell fate determination
Périodique
Nature
Auteur(s)
Nishimura  E. K., Jordan  S. A., Oshima  H., Yoshida  H., Osawa  M., Moriyama  M., Jackson  I. J., Barrandon  Y., Miyachi  Y., Nishikawa  S.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
04/2002
Volume
416
Numéro
6883
Pages
854-60
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr 25
Résumé
Stem cells which have the capacity to self-renew and generate differentiated progeny are thought to be maintained in a specific environment known as a niche. The localization of the niche, however, remains largely obscure for most stem-cell systems. Melanocytes (pigment cells) in hair follicles proliferate and differentiate closely coupled to the hair regeneration cycle. Here we report that stem cells of the melanocyte lineage can be identified, using Dct-lacZ transgenic mice, in the lower permanent portion of mouse hair follicles throughout the hair cycle. It is only the population in this region that fulfils the criteria for stem cells, being immature, slow cycling, self-maintaining and fully competent in regenerating progeny on activation at early anagen (the growing phase of hair follicles). Induction of the re-pigmentation process in K14-steel factor transgenic mice demonstrates that a portion of amplifying stem-cell progeny can migrate out from the niche and retain sufficient self-renewing capability to function as stem cells after repopulation into vacant niches. Our data indicate that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny.
Mots-clé
Animals *Cell Differentiation Cell Division *Cell Lineage Cell Movement Genes, Reporter/genetics Hair Color Hair Follicle/*cytology/metabolism Immunohistochemistry Melanocytes/*cytology/metabolism Mice Mice, Inbred C57BL Mice, Transgenic Oncogene Proteins/physiology Proto-Oncogene Proteins c-kit Stem Cells/*cytology/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 9:41
Dernière modification de la notice
20/08/2019 14:58
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