Dosage et cinetique de liberation de mitomycine C d'un implant de collagene utilise comme moyen d'administration lors d'une chirurgie filtrante chez le lapin. [Dosage and kinetics of MMC release of a collagen implant used as a delivery device in glaucoma surgery in the rabbit eye]

Détails

ID Serval
serval:BIB_4A382164FC7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dosage et cinetique de liberation de mitomycine C d'un implant de collagene utilise comme moyen d'administration lors d'une chirurgie filtrante chez le lapin. [Dosage and kinetics of MMC release of a collagen implant used as a delivery device in glaucoma surgery in the rabbit eye]
Périodique
Journal Français d'Ophtalmologie
Auteur(s)
Adjadj  E., Roy  S., Zimmermann  C., Shaarawy  T., Flammer  J., Mermoud  A., Drewe  J.
ISSN
1773-0597 (Electronic)
Statut éditorial
Publié
Date de publication
11/2006
Volume
29
Numéro
9
Pages
1042-6
Notes
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
PURPOSE: To determine the absorption and the release of mitomycin-C from a collagen implant and tissue impregnation in the anterior structures of the rabbit eye. METHODS: Determining the quantity of mitomycin-C that a collagen implant can absorb with the difference between dry and soaked weight. Mitomycin-C release was measured in vitro using spectrophotometry. The measurement was repeated using a bioassay. Ocular tissue impregnation was determined in 12 eyes of six rabbits. Sclera, implant, aqueous, and ciliary body specimens were collected for concentration measurement using HPLC from 1 to 6 h after surgery. RESULTS: The mean mitomycin-C quantity absorbed in the implant was 3.22+/-0.2 microg. In vitro release was 0.13 mg/ml after 10 min and 0.05 microg/ml at 6 h. The bioassay showed almost no antifibrotic activity in sclera. In vivo release of mitomycin-C was high from the first to the sixth hour. CONCLUSION: After filtering surgery, mitomycin-C in the collagen implant is clearly released and ocular tissues are effectively impregnated.
Mots-clé
Animals Cicatrix/prevention & control Collagen *Drug Delivery Systems *Filtering Surgery/adverse effects Glaucoma/*surgery Mitomycin/*administration & dosage/*pharmacokinetics *Prostheses and Implants Rabbits
Pubmed
Web of science
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
20/08/2019 13:57
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