Preoperative localization of parathyroid adenoma with sonography and 99mTc-sestamibi scintigraphy in primary hyperparathyroidism.
Détails
ID Serval
serval:BIB_4A2DC809ED06
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Preoperative localization of parathyroid adenoma with sonography and 99mTc-sestamibi scintigraphy in primary hyperparathyroidism.
Périodique
Journal of clinical ultrasound
ISSN
0091-2751 (Print)
ISSN-L
0091-2751
Statut éditorial
Publié
Date de publication
05/2007
Peer-reviewed
Oui
Volume
35
Numéro
4
Pages
186-190
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To evaluate the sensitivity, specificity, and usefulness of dual-phase 99mTc-Sestamibi scintigraphy (SS) and sonography (US) of the neck, alone and in combination, as noninvasive adenoma localizing procedures in patients with primary hyperparathyroidism prior to parathyroidectomy.
We retrospectively analyzed the charts of 79 patients with parathyroid (PT) adenomas and confirmed diagnosis of hyperparathyroidism who were evaluated with SS and US prior to successful parathyroidectomy.
Ninety-three adenomas were removed during bilateral neck exploration. SS alone showed a sensitivity of 76% and a specificity of 79% compared with 89% and 75%, respectively, for US performed after SS on the same day. Combination of the 2 procedures yielded a sensitivity of 89% and a specificity of 90%, with 22% discordant results. The differences in sensitivity and specificity between the 2 techniques alone or in combination were not statistically significant.
No benefit was gained from using both SS and US for the preoperative localization of PT adenomas in patients with primary hyperparathyroidism. Each technique can be negatively affected by thyroid enlargement and nodularity. US, when performed by a skilled operator, is a reliable tool for PT adenoma localization. If the US findings are inconclusive, SS should be used.
We retrospectively analyzed the charts of 79 patients with parathyroid (PT) adenomas and confirmed diagnosis of hyperparathyroidism who were evaluated with SS and US prior to successful parathyroidectomy.
Ninety-three adenomas were removed during bilateral neck exploration. SS alone showed a sensitivity of 76% and a specificity of 79% compared with 89% and 75%, respectively, for US performed after SS on the same day. Combination of the 2 procedures yielded a sensitivity of 89% and a specificity of 90%, with 22% discordant results. The differences in sensitivity and specificity between the 2 techniques alone or in combination were not statistically significant.
No benefit was gained from using both SS and US for the preoperative localization of PT adenomas in patients with primary hyperparathyroidism. Each technique can be negatively affected by thyroid enlargement and nodularity. US, when performed by a skilled operator, is a reliable tool for PT adenoma localization. If the US findings are inconclusive, SS should be used.
Mots-clé
Adenoma/diagnostic imaging, Adult, Aged, Aged, 80 and over, Female, Humans, Hyperparathyroidism, Primary/diagnostic imaging, Intraoperative Care, Male, Middle Aged, Parathyroid Hormone/analysis, Parathyroid Neoplasms/diagnostic imaging, Parathyroidectomy, Postoperative Complications, Radionuclide Imaging, Radiopharmaceuticals, Recurrent Laryngeal Nerve/physiopathology, Retrospective Studies, Sensitivity and Specificity, Technetium Tc 99m Sestamibi, Thyroid Gland/diagnostic imaging, Thyroid Nodule/diagnostic imaging, Ultrasonography, Vocal Cord Paralysis/etiology
Pubmed
Web of science
Création de la notice
16/01/2020 15:32
Dernière modification de la notice
17/01/2020 7:26