Energy-nitrogen balances and protein turnover in small and appropriate for gestational age low birthweight infants.

Détails

ID Serval
serval:BIB_49B89F147007
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Energy-nitrogen balances and protein turnover in small and appropriate for gestational age low birthweight infants.
Périodique
European Journal of Clinical Nutrition
Auteur⸱e⸱s
Cauderay M., Schutz Y., Micheli J.L., Calame A., Jéquier E.
ISSN
0954-3007 (Print)
ISSN-L
0954-3007
Statut éditorial
Publié
Date de publication
1988
Volume
42
Numéro
2
Pages
125-136
Langue
anglais
Résumé
The aim of the present study was to compare, under the same nursing conditions, the energy-nitrogen balance and the protein turnover in small for gestational age (SGA) and appropriate for gestational age (AGA) low birthweight infants. We compared 8 SGA's (mean +/- s.d.: gestational age 35 +/- 2 weeks, birthweight 1520 +/- 330 g) to 11 AGA premature infants (32 +/- 2 weeks, birthweight 1560 +/- 240 g). When their rate of weight gain was above 15 g/kg/d (17.6 +/- 3.0 and 18.2 +/- 2.6 g/kg/d, mean postnatal age 18 +/- 10 and 20 +/- 9 d respectively) they were studied with respect to their metabolizable energy intake, their energy expenditure, their energy and protein gain and their protein turnover. Energy balance was assessed by the difference between metabolizable energy and energy expenditure as measured by indirect calorimetry. Protein gain was calculated from the amount of retained nitrogen. Protein turnover was estimated by a stable isotope enrichment technique using repeated nasogastric administration of 15N-glycine for 72 h. Although there was no difference in their metabolizable energy intakes (110 +/- 12 versus 108 +/- 11 kcal/kg/d), SGA's had a higher rate of resting energy expenditure (64 +/- 8 versus 57 +/- 8 kcal/kg/d, P less than 0.05). Protein gain and composition of weight gain was very similar in both groups (2.0 +/- 0.4 versus 2.1 +/- 0.4 g protein/kg/d; 3.5 +/- 1.1 versus 3.3 +/- 1.4 g fat/kg/d in SGA's and AGA's respectively). However, the rate of protein synthesis was significantly lower in SGA's (7.7 +/- 1.6 g/kg/d) as compared to AGA's (9.7 +/- 2.8 g/kg/d; P less than 0.05). It is concluded that SGA's have a more efficient protein gain/protein synthesis ratio since for the same weight and protein gains, SGA's show a 20 per cent slower protein turnover. They might therefore tolerate slightly higher protein intakes. Postconceptional age seems to be an important factor in the regulation of protein turnover.
Mots-clé
Blood Urea Nitrogen, Calorimetry, Dietary Proteins/metabolism, Energy Intake, Energy Metabolism, Female, Glucose/metabolism, Growth, Humans, Infant, Newborn, Infant, Small for Gestational Age/metabolism, Lipid Peroxides/metabolism, Male, Nitrogen/metabolism
Pubmed
Web of science
Création de la notice
21/01/2008 14:08
Dernière modification de la notice
20/08/2019 14:57
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