Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy.

Détails

ID Serval
serval:BIB_49A26876BD66
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy.
Périodique
Trends in cancer
Auteur⸱e⸱s
Wang H., Franco F., Ho P.C.
ISSN
2405-8025 (Electronic)
ISSN-L
2405-8025
Statut éditorial
Publié
Date de publication
08/2017
Peer-reviewed
Oui
Volume
3
Numéro
8
Pages
583-592
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The promising outcomes observed in cancer immunotherapy are evidence that the immune system provides a powerful arsenal for the restriction of tumor outgrowth; however, the immunosuppressive tumor microenvironment (TME) is known to impair antitumor immunity and impede the efficacy of cancer immunotherapies. Regulatory T cells (Tregs), which prevent overt immune responses and autoimmunity, accumulate aberrantly in some types of tumor to suppress antitumor immunity and support the establishment of an immunosuppressive microenvironment. Ablation of Tregs has been shown to not only unleash antitumor immunity and interrupt formation of an immunosuppressive TME, but also lead to severe autoimmune disorders. Therefore, it is essential to develop approaches to specifically target intratumoral Tregs. Herein, we summarize the immunomodulatory functions of Tregs in the TME and discuss how metabolic regulation of Tregs can facilitate intratumoral Treg accumulation.
Mots-clé
Animals, Antineoplastic Agents, Immunological/pharmacology, Antineoplastic Agents, Immunological/therapeutic use, Autoimmunity, Humans, Immune Tolerance/drug effects, Immune Tolerance/immunology, Immunotherapy/methods, Immunotherapy/trends, Mice, Neoplasms/immunology, Neoplasms/therapy, Signal Transduction/drug effects, Signal Transduction/immunology, T-Lymphocytes, Regulatory/drug effects, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Tumor Escape/drug effects, Tumor Escape/immunology, Tumor Microenvironment/drug effects, Tumor Microenvironment/immunology, cancer immunology, immunometabolism, immunosuppressive, regulatory T cell, tumor microenvironment
Pubmed
Web of science
Création de la notice
05/09/2017 17:24
Dernière modification de la notice
20/08/2019 14:57
Données d'usage