Signal transduction in neutrophil chemotaxis.

Détails

ID Serval
serval:BIB_499D376C3E81
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Signal transduction in neutrophil chemotaxis.
Périodique
Biochemistry
Auteur(s)
Katanaev V.L.
ISSN
0006-2979 (Print)
ISSN-L
0006-2979
Statut éditorial
Publié
Date de publication
2001
Volume
66
Numéro
4
Pages
351-368
Langue
anglais
Résumé
This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-helix receptors. These receptors activate trimeric G proteins of the Gi class in neutrophils to initiate chemotaxis. Phospholipases Cbeta, phosphoinositide 3-kinase gamma, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the "compass" of chemotaxing cells, which may involve Cdc42 and certain PH domain-containing proteins, are also presented.
Mots-clé
Animals, Cell Movement/physiology, Chemotactic Factors/physiology, Chemotaxis, Leukocyte/physiology, GTP-Binding Proteins/chemistry, GTP-Binding Proteins/metabolism, Humans, Neutrophils/cytology, Neutrophils/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Receptors, Formyl Peptide, Receptors, Immunologic/chemistry, Receptors, Immunologic/metabolism, Receptors, Peptide/chemistry, Receptors, Peptide/metabolism, Signal Transduction/physiology, cdc42 GTP-Binding Protein/physiology, rho GTP-Binding Proteins/physiology
Pubmed
Web of science
Création de la notice
09/07/2012 10:09
Dernière modification de la notice
20/08/2019 14:57
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