Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae.

Détails

ID Serval
serval:BIB_4995B5C8D285
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae.
Périodique
Microbes and infection
Auteur(s)
Lamoth F., Pillonel T., Greub G.
ISSN
1769-714X (Electronic)
ISSN-L
1286-4579
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
17
Numéro
11-12
Pages
732-737
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Waddlia chondrophila is an emerging pathogen associated with abortion in cattle. In humans, a growing body of evidence supports its pathogenic role in miscarriage and in respiratory tract infection. The human pathogenicity of W. chondrophila is further supported by the presence of several virulence factors including a catalase, a functional T3SS and several adhesins. Despite this medical importance, no commercial tests are available and diagnostic of this strict intracellular bacterium mainly relies on serology, PCR and immunohistochemistry. So far, the epidemiology of W. chondrophila remains largely unexplored and zoonotic, waterborne or interhuman transmission has been considered. Apart from its pathogenic role, chlamydiologists are also interested in W. chondrophila in order to better understand biological mechanisms conserved and shared with Chlamydia spp. Indeed, W. chondrophila proved to be a useful model organism to study the pathobiology of chlamydiae thanks to its rapid replication, its large size allowing precise subcellular protein localization, as well as its growth in Dictyostelium amoebae.
Mots-clé
Abortion, Spontaneous/microbiology, Abortion, Veterinary/microbiology, Animals, Cattle, Cattle Diseases/microbiology, Chlamydiales/pathogenicity, Female, Humans, Intracellular Space/microbiology, Pregnancy, Virulence Factors, Chlamydia-like organism, Emerging pathogen, Intracellular bacteria, Miscarriage, Model organism
Pubmed
Web of science
Création de la notice
03/10/2019 17:01
Dernière modification de la notice
04/10/2019 6:26
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